Induction of Th1 and Th2 CD4 super(+) subsets during murine Leishmania major) infection

Induction of Th1 and Th2 CD4 super(+) subsets during murine Leishmania major) infection

Infection of inbred strains of mice with Leishmania major results in strain-specific reproduction of the spectrum of disease that occurs in humans with L. donovani infections; self-limited cure occurs in most strains, such as C57BL/6 and C3H/HeN, whereas the BALB/c mouse is unable to control infecti...

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Veröffentlicht in:Research in immunology (Paris) 1991-01, Vol.142 (1), p.28-32
Hauptverfasser: Locksley, R M, Heinzel, F P, Holaday, B J, Mutha, S S, Reiner, S L, Sadick, MD
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Leishmania major
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container_title Research in immunology (Paris)
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creator Locksley, R M
Heinzel, F P
Holaday, B J
Mutha, S S
Reiner, S L
Sadick, MD
description Infection of inbred strains of mice with Leishmania major results in strain-specific reproduction of the spectrum of disease that occurs in humans with L. donovani infections; self-limited cure occurs in most strains, such as C57BL/6 and C3H/HeN, whereas the BALB/c mouse is unable to control infection and dies of progressive visceral disease that mimics human kala-azar. Infection in both resistant and susceptible strains of mice is associated with activation of CD4 super(+) T lymphocytes in vivo as assessed by expansion in number in the draining lymph nodes and the appearance of lymphokine mRNA in vivo.
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source Alma/SFX Local Collection
subjects Leishmania major
title Induction of Th1 and Th2 CD4 super(+) subsets during murine Leishmania major) infection
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