Productive and non-productive binding of botulinum neurotoxin A to motor nerve endings are distinguished by its heavy chain

Botulinum neurotoxin type A, a di‐chain protein produced by Clostridium botulinum and responsible for botulism, blocks acetylcholine release from peripheral nerves by binding to the terminals, undergoing internalization and proteolyzing a protein essential for exocytosis. As botulinum neurotoxin is...

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