Lung and blood superoxide dismutase activity in mercury vapor exposed rats: effect of N-acetylcysteine treatment
Rats were exposed to mercury vapors (30 mg/m 3) for either 1 or 2 h. Histological lesions like alveolar oedema, hyaline membranes and sometimes fibrosis were observed. The lesions were more significant after 2 h of exposure, with about 50% of the animals dying within 2 weeks. The mercury level and t...
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| Veröffentlicht in: | Toxicology (Amsterdam) 1991-03, Vol.66 (3), p.289-295 |
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| creator | Livardjani, Fariborz Ledig, Marc Kopp, Patrick Dahlet, Marc Leroy, Maurice Jaeger, Albert |
| description | Rats were exposed to mercury vapors (30 mg/m
3) for either 1 or 2 h. Histological lesions like alveolar oedema, hyaline membranes and sometimes fibrosis were observed. The lesions were more significant after 2 h of exposure, with about 50% of the animals dying within 2 weeks. The mercury level and the superoxide dismutase activity in the blood and the lungs demonstrated differences according to the time of exposure. In the animal exposed for 2 h to mercury vapors,
N-acetylcysteine treatment increased survival time and the percentage of living animals. The lung superoxide dismutase was lower than in the non-treated animals indicating an antioxidant effect. Mercury levels were decreased in blood and lung, suggesting some chelating effect of
N-acetylcysteine. The exact mechanism of its action must be further elucidated. |
| doi_str_mv | 10.1016/0300-483X(91)90200-K |
| format | Article |
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3) for either 1 or 2 h. Histological lesions like alveolar oedema, hyaline membranes and sometimes fibrosis were observed. The lesions were more significant after 2 h of exposure, with about 50% of the animals dying within 2 weeks. The mercury level and the superoxide dismutase activity in the blood and the lungs demonstrated differences according to the time of exposure. In the animal exposed for 2 h to mercury vapors,
N-acetylcysteine treatment increased survival time and the percentage of living animals. The lung superoxide dismutase was lower than in the non-treated animals indicating an antioxidant effect. Mercury levels were decreased in blood and lung, suggesting some chelating effect of
N-acetylcysteine. The exact mechanism of its action must be further elucidated.</description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/0300-483X(91)90200-K</identifier><identifier>PMID: 2011853</identifier><identifier>CODEN: TXICDD</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acetylcysteine - therapeutic use ; Administration, Inhalation ; Animals ; Biological and medical sciences ; Blood ; Chemical and industrial products toxicology. Toxic occupational diseases ; Lung ; Lung - drug effects ; Lung - enzymology ; Male ; Medical sciences ; Mercury ; Mercury - antagonists & inhibitors ; Mercury - blood ; Mercury - toxicity ; Metals and various inorganic compounds ; N-acetylcysteine ; Rat ; Rats ; Rats, Inbred Strains ; Superoxide dismutase ; Superoxide Dismutase - blood ; Superoxide Dismutase - metabolism ; Toxicology</subject><ispartof>Toxicology (Amsterdam), 1991-03, Vol.66 (3), p.289-295</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-fe6bcc1cec55cae185fb067eaa24bdf11ecbf1a917f1b567b2898c94de0569363</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0300483X9190200K$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19645493$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2011853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Livardjani, Fariborz</creatorcontrib><creatorcontrib>Ledig, Marc</creatorcontrib><creatorcontrib>Kopp, Patrick</creatorcontrib><creatorcontrib>Dahlet, Marc</creatorcontrib><creatorcontrib>Leroy, Maurice</creatorcontrib><creatorcontrib>Jaeger, Albert</creatorcontrib><title>Lung and blood superoxide dismutase activity in mercury vapor exposed rats: effect of N-acetylcysteine treatment</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description>Rats were exposed to mercury vapors (30 mg/m
3) for either 1 or 2 h. Histological lesions like alveolar oedema, hyaline membranes and sometimes fibrosis were observed. The lesions were more significant after 2 h of exposure, with about 50% of the animals dying within 2 weeks. The mercury level and the superoxide dismutase activity in the blood and the lungs demonstrated differences according to the time of exposure. In the animal exposed for 2 h to mercury vapors,
N-acetylcysteine treatment increased survival time and the percentage of living animals. The lung superoxide dismutase was lower than in the non-treated animals indicating an antioxidant effect. Mercury levels were decreased in blood and lung, suggesting some chelating effect of
N-acetylcysteine. The exact mechanism of its action must be further elucidated.</description><subject>Acetylcysteine - therapeutic use</subject><subject>Administration, Inhalation</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Lung</subject><subject>Lung - drug effects</subject><subject>Lung - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mercury</subject><subject>Mercury - antagonists & inhibitors</subject><subject>Mercury - blood</subject><subject>Mercury - toxicity</subject><subject>Metals and various inorganic compounds</subject><subject>N-acetylcysteine</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - blood</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Toxicology</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi1EVZbCG4DkCwgOAU_iZOMekFAFFHUFF5C4Wc54jIySONjOqnl7suyqvfU0Gs33_xp9jL0A8Q4ENO9FJUQh2-rXGwVvlSjX7eYR20C7VUUFbf2Ybe6QJ-xpSn-EEGUlm3N2XgpYiWrDpt08_uZmtLzrQ7A8zRPFcOstcevTMGeTiBvMfu_zwv3IB4o4x4XvzRQip9spJLI8mpwuOTlHmHlw_FthkPLS45Iy-ZF4jmTyQGN-xs6c6RM9P80L9vPzpx9X18Xu-5evVx93BUpoc-Go6RABCesaDa3Puk40WzKmlJ11AISdA6Ng66Crm21XtqpFJS2JulFVU12w18feKYa_M6WsB5-Q-t6MFOakoVZSgCpXUB5BjCGlSE5P0Q8mLhqEPojWB4v6YFEr0P9F65s19vLUP3cD2bvQyex6f3W6m4Smd9GM6NN9t2pkLdWB-3DkaJWx9xR1Qk8jkvVxlalt8A8_8g-S-50i</recordid><startdate>19910311</startdate><enddate>19910311</enddate><creator>Livardjani, Fariborz</creator><creator>Ledig, Marc</creator><creator>Kopp, Patrick</creator><creator>Dahlet, Marc</creator><creator>Leroy, Maurice</creator><creator>Jaeger, Albert</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19910311</creationdate><title>Lung and blood superoxide dismutase activity in mercury vapor exposed rats: effect of N-acetylcysteine treatment</title><author>Livardjani, Fariborz ; Ledig, Marc ; Kopp, Patrick ; Dahlet, Marc ; Leroy, Maurice ; Jaeger, Albert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-fe6bcc1cec55cae185fb067eaa24bdf11ecbf1a917f1b567b2898c94de0569363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acetylcysteine - therapeutic use</topic><topic>Administration, Inhalation</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Chemical and industrial products toxicology. 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| ispartof | Toxicology (Amsterdam), 1991-03, Vol.66 (3), p.289-295 |
| issn | 0300-483X 1879-3185 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcysteine - therapeutic use Administration, Inhalation Animals Biological and medical sciences Blood Chemical and industrial products toxicology. Toxic occupational diseases Lung Lung - drug effects Lung - enzymology Male Medical sciences Mercury Mercury - antagonists & inhibitors Mercury - blood Mercury - toxicity Metals and various inorganic compounds N-acetylcysteine Rat Rats Rats, Inbred Strains Superoxide dismutase Superoxide Dismutase - blood Superoxide Dismutase - metabolism Toxicology |
| title | Lung and blood superoxide dismutase activity in mercury vapor exposed rats: effect of N-acetylcysteine treatment |
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