THE EFFECT OF FOOD ON THE PHARMACOKINETICS OF MULTIPLE‐DOSE TERBINAFINE IN YOUNG AND ELDERLY HEALTHY SUBJECTS

Pharmacokinetic (PK) parameters for terbinafine were assessed in 15 elderly and 15 young healthy subjects randomized to receive 250 mg Lamisil™ once daily for 15 d in a two‐period, two‐treatment, two‐sequence, crossover (fed versus fasted) design within age groups. On each treatment day except days...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 1997-03, Vol.18 (2), p.127-138
Hauptverfasser:	NEDELMAN, JERRY, CRAMER, JEFFREY A., ROBBINS, BRUCE, GIBIANSKY, EKATERINA, CHANG, CHENG‐TAO, GAREFFA, STEPHEN, COHEN, ALBERT, MELIGENI, JOHN
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - adverse effects Antifungal Agents - pharmacokinetics Biological and medical sciences Biological Availability compartmental modeling Cross-Over Studies Food Humans Lamisil Medical sciences Middle Aged Models, Biological Models, Statistical Naphthalenes - adverse effects Naphthalenes - pharmacokinetics onychomycosis pharmacokinetics Pharmacology. Drug treatments Reference Values
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