The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA breakage (Comet assay)

The ability of fluoroquinolones to cause light-induced adverse effects has been established in experimental studies and clinical observations. The formation of active oxygen species appears to be responsible for this activity. Photo-mutagenicity tests with bacterial, lower eukaryotic and mammalian c...

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Veröffentlicht in:	Mutagenesis 1996-09, Vol.11 (5), p.497-504
Hauptverfasser:	Chételat, Andrée-Anne, Albertini, Silvio, Gocke, Elmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - radiation effects Anti-Infective Agents - toxicity Biological and medical sciences Carcinogens - toxicity Chromosome Aberrations Ciprofloxacin - chemistry Ciprofloxacin - radiation effects Ciprofloxacin - toxicity Cricetinae DNA Damage - drug effects Drug toxicity and drugs side effects treatment Fleroxacin - chemistry Fleroxacin - radiation effects Fleroxacin - toxicity Fluoroquinolones Gene Conversion - drug effects Lymphoma - genetics Lymphoma - pathology Lymphoma - therapy Medical sciences Methoxsalen - toxicity Mice Miscellaneous (drug allergy, mutagens, teratogens...) Mitosis - drug effects Mutagenicity Tests - methods Mutagens - toxicity Mutation - drug effects Pharmacology. Drug treatments Photosensitizing Agents - toxicity Quinolones - chemistry Quinolones - radiation effects Quinolones - toxicity Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Salmonella - drug effects Salmonella - genetics Salmonella typhimurium Tumor Cells, Cultured Ultraviolet Rays
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