Lack of effects of some individual polybrominated diphenyl ether (PBDE) and polychlorinated biphenyl (PCB) congeners on human lymphocyte functions in vitro
The structural similarities between polybrominated diphenyl ethers and immunotoxic halogenated aromatic compounds suggest that the polybrominated diphenyl ethers might affect the immune system. The present study was undertaken to investigate the immunological effects of some purified PBDE-congeners...
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| Veröffentlicht in: | Toxicology letters 1997-02, Vol.90 (2), p.189-197 |
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| creator | Fernlöf, Gunilla Gadhasson, Ingalill Pödra, Kerstin Ola Darnerud, Per Thuvander, Ann |
| description | The structural similarities between polybrominated diphenyl ethers and immunotoxic halogenated aromatic compounds suggest that the polybrominated diphenyl ethers might affect the immune system. The present study was undertaken to investigate the immunological effects of some purified PBDE-congeners on human lymphocyte function in vitro. Polychlorinated biphenyl congeners were also included in the study. Mitogen-induced DNA synthesis and immunoglobulin synthesis by lymphocytes from blood donors were examined following polybrominated diphenyl ether or polychlorinated biphenyl exposure in vitro in order to determine the immunotoxic potential of these substances. No effects on mitogen-induced proliferation or immunoglobulin synthesis were observed after exposure of cells to concentrations up to 10
−5 M. The negative findings in this study indicate that certain functions of human peripheral lymphocytes, i.e. proliferation and immunoglobulin synthesis, are insensitive to the direct action of polybrominated diphenyl ethers and polychlorinated biphenyls. Our results are in accordance with other recent studies in which no effects on immunological parameters were demonstrated by exposure of lymphocytes to polyhalogenated aromatic hydrocarbons in vitro. |
| doi_str_mv | 10.1016/S0378-4274(96)03848-9 |
| format | Article |
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−5 M. The negative findings in this study indicate that certain functions of human peripheral lymphocytes, i.e. proliferation and immunoglobulin synthesis, are insensitive to the direct action of polybrominated diphenyl ethers and polychlorinated biphenyls. Our results are in accordance with other recent studies in which no effects on immunological parameters were demonstrated by exposure of lymphocytes to polyhalogenated aromatic hydrocarbons in vitro.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/S0378-4274(96)03848-9</identifier><identifier>PMID: 9067487</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Cells, Cultured ; Chemical agents ; Flame Retardants - toxicity ; Halogenated Diphenyl Ethers ; Human lymphocyte function ; Humans ; Hydrocarbons, Brominated - chemistry ; Hydrocarbons, Brominated - toxicity ; Immune system ; Immunoglobulins - biosynthesis ; Lymphocyte Activation - drug effects ; Lymphocytes - drug effects ; Lymphocytes - immunology ; Medical sciences ; Phenyl Ethers - chemistry ; Phenyl Ethers - toxicity ; Polybrominated Biphenyls - chemistry ; Polybrominated Biphenyls - toxicity ; Polybrominated diphenyl ethers (PBDE) ; Polychlorinated biphenyls (PCB) ; Polychlorinated Biphenyls - chemistry ; Polychlorinated Biphenyls - toxicity ; Tumors</subject><ispartof>Toxicology letters, 1997-02, Vol.90 (2), p.189-197</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-f3057b6d0c1cb703cb8653b6830cd8305d73fd73ae5b7b2d9f99aeba302dda5d3</citedby><cites>FETCH-LOGICAL-c420t-f3057b6d0c1cb703cb8653b6830cd8305d73fd73ae5b7b2d9f99aeba302dda5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378427496038489$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2583342$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9067487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernlöf, Gunilla</creatorcontrib><creatorcontrib>Gadhasson, Ingalill</creatorcontrib><creatorcontrib>Pödra, Kerstin</creatorcontrib><creatorcontrib>Ola Darnerud, Per</creatorcontrib><creatorcontrib>Thuvander, Ann</creatorcontrib><title>Lack of effects of some individual polybrominated diphenyl ether (PBDE) and polychlorinated biphenyl (PCB) congeners on human lymphocyte functions in vitro</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>The structural similarities between polybrominated diphenyl ethers and immunotoxic halogenated aromatic compounds suggest that the polybrominated diphenyl ethers might affect the immune system. The present study was undertaken to investigate the immunological effects of some purified PBDE-congeners on human lymphocyte function in vitro. Polychlorinated biphenyl congeners were also included in the study. Mitogen-induced DNA synthesis and immunoglobulin synthesis by lymphocytes from blood donors were examined following polybrominated diphenyl ether or polychlorinated biphenyl exposure in vitro in order to determine the immunotoxic potential of these substances. No effects on mitogen-induced proliferation or immunoglobulin synthesis were observed after exposure of cells to concentrations up to 10
−5 M. The negative findings in this study indicate that certain functions of human peripheral lymphocytes, i.e. proliferation and immunoglobulin synthesis, are insensitive to the direct action of polybrominated diphenyl ethers and polychlorinated biphenyls. Our results are in accordance with other recent studies in which no effects on immunological parameters were demonstrated by exposure of lymphocytes to polyhalogenated aromatic hydrocarbons in vitro.</description><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Cells, Cultured</subject><subject>Chemical agents</subject><subject>Flame Retardants - toxicity</subject><subject>Halogenated Diphenyl Ethers</subject><subject>Human lymphocyte function</subject><subject>Humans</subject><subject>Hydrocarbons, Brominated - chemistry</subject><subject>Hydrocarbons, Brominated - toxicity</subject><subject>Immune system</subject><subject>Immunoglobulins - biosynthesis</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - immunology</subject><subject>Medical sciences</subject><subject>Phenyl Ethers - chemistry</subject><subject>Phenyl Ethers - toxicity</subject><subject>Polybrominated Biphenyls - chemistry</subject><subject>Polybrominated Biphenyls - toxicity</subject><subject>Polybrominated diphenyl ethers (PBDE)</subject><subject>Polychlorinated biphenyls (PCB)</subject><subject>Polychlorinated Biphenyls - chemistry</subject><subject>Polychlorinated Biphenyls - toxicity</subject><subject>Tumors</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuO0zAUhiMEGjoDjzCSFwi1i4ATJ068QkwZLlIlRgLWli_HxJDYxU4q5Vl42XHb0C0LX6TzHf_W-bLstsBvClzQt98wadq8KptqzegGk7Zqc_YkWxVtw3JSUPY0W12Q59l1jL8wxrSi9VV2xTBtqrZZZX93Qv1G3iAwBtQYj9foB0DWaXuwehI92vt-lsEP1okRNNJ234GbewRjBwGtH-4-3G-QcPoEqq73YSHlP3L9sL3bIOXdT3AQUohD3TQIh_p52HdezSMgMzk1Wu9iikYHOwb_IntmRB_h5XLeZD8-3n_ffs53Xz992b7f5aoq8ZgbgutGUo1VoWSDiZItrYmkLcFKp63WDTFpCahlI0vNDGMCpCC41FrUmtxkr8_v7oP_M0Ec-WCjgr4XDvwUeVGzsqCYJrA-gyr4GAMYvg92EGHmBeZHKfwkhR8nzhnlJymcpb7bJWCSA-hL12Ih1V8tdRGV6E0QTtl4wcq6JaQqE_bujEEaxsFC4FFZcAq0Dckd197-5yOPANOr_Q</recordid><startdate>19970207</startdate><enddate>19970207</enddate><creator>Fernlöf, Gunilla</creator><creator>Gadhasson, Ingalill</creator><creator>Pödra, Kerstin</creator><creator>Ola Darnerud, Per</creator><creator>Thuvander, Ann</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19970207</creationdate><title>Lack of effects of some individual polybrominated diphenyl ether (PBDE) and polychlorinated biphenyl (PCB) congeners on human lymphocyte functions in vitro</title><author>Fernlöf, Gunilla ; Gadhasson, Ingalill ; Pödra, Kerstin ; Ola Darnerud, Per ; Thuvander, Ann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-f3057b6d0c1cb703cb8653b6830cd8305d73fd73ae5b7b2d9f99aeba302dda5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Cells, Cultured</topic><topic>Chemical agents</topic><topic>Flame Retardants - toxicity</topic><topic>Halogenated Diphenyl Ethers</topic><topic>Human lymphocyte function</topic><topic>Humans</topic><topic>Hydrocarbons, Brominated - chemistry</topic><topic>Hydrocarbons, Brominated - toxicity</topic><topic>Immune system</topic><topic>Immunoglobulins - biosynthesis</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - immunology</topic><topic>Medical sciences</topic><topic>Phenyl Ethers - chemistry</topic><topic>Phenyl Ethers - toxicity</topic><topic>Polybrominated Biphenyls - chemistry</topic><topic>Polybrominated Biphenyls - toxicity</topic><topic>Polybrominated diphenyl ethers (PBDE)</topic><topic>Polychlorinated biphenyls (PCB)</topic><topic>Polychlorinated Biphenyls - chemistry</topic><topic>Polychlorinated Biphenyls - toxicity</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernlöf, Gunilla</creatorcontrib><creatorcontrib>Gadhasson, Ingalill</creatorcontrib><creatorcontrib>Pödra, Kerstin</creatorcontrib><creatorcontrib>Ola Darnerud, Per</creatorcontrib><creatorcontrib>Thuvander, Ann</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernlöf, Gunilla</au><au>Gadhasson, Ingalill</au><au>Pödra, Kerstin</au><au>Ola Darnerud, Per</au><au>Thuvander, Ann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of effects of some individual polybrominated diphenyl ether (PBDE) and polychlorinated biphenyl (PCB) congeners on human lymphocyte functions in vitro</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>1997-02-07</date><risdate>1997</risdate><volume>90</volume><issue>2</issue><spage>189</spage><epage>197</epage><pages>189-197</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>The structural similarities between polybrominated diphenyl ethers and immunotoxic halogenated aromatic compounds suggest that the polybrominated diphenyl ethers might affect the immune system. The present study was undertaken to investigate the immunological effects of some purified PBDE-congeners on human lymphocyte function in vitro. Polychlorinated biphenyl congeners were also included in the study. Mitogen-induced DNA synthesis and immunoglobulin synthesis by lymphocytes from blood donors were examined following polybrominated diphenyl ether or polychlorinated biphenyl exposure in vitro in order to determine the immunotoxic potential of these substances. No effects on mitogen-induced proliferation or immunoglobulin synthesis were observed after exposure of cells to concentrations up to 10
−5 M. The negative findings in this study indicate that certain functions of human peripheral lymphocytes, i.e. proliferation and immunoglobulin synthesis, are insensitive to the direct action of polybrominated diphenyl ethers and polychlorinated biphenyls. Our results are in accordance with other recent studies in which no effects on immunological parameters were demonstrated by exposure of lymphocytes to polyhalogenated aromatic hydrocarbons in vitro.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>9067487</pmid><doi>10.1016/S0378-4274(96)03848-9</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 1997-02, Vol.90 (2), p.189-197 |
| issn | 0378-4274 1879-3169 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cells, Cultured Chemical agents Flame Retardants - toxicity Halogenated Diphenyl Ethers Human lymphocyte function Humans Hydrocarbons, Brominated - chemistry Hydrocarbons, Brominated - toxicity Immune system Immunoglobulins - biosynthesis Lymphocyte Activation - drug effects Lymphocytes - drug effects Lymphocytes - immunology Medical sciences Phenyl Ethers - chemistry Phenyl Ethers - toxicity Polybrominated Biphenyls - chemistry Polybrominated Biphenyls - toxicity Polybrominated diphenyl ethers (PBDE) Polychlorinated biphenyls (PCB) Polychlorinated Biphenyls - chemistry Polychlorinated Biphenyls - toxicity Tumors |
| title | Lack of effects of some individual polybrominated diphenyl ether (PBDE) and polychlorinated biphenyl (PCB) congeners on human lymphocyte functions in vitro |
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