Malonate‐Induced Degeneration of Basal Forebrain Cholinergic Neurons: Attenuation by Lamotrigine, MK‐801, and 7‐Nitroindazole

: Previously, we have reported that intranigral infusions of malonate, an inhibitor of mitochondrial function, lead to the degeneration of the dopaminergic neurons of the nigrostriatal pathway that is mediated, at least in part, through NMDA receptor activation and nitric oxide formation. In the pre...

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Veröffentlicht in:	Journal of neurochemistry 1997-03, Vol.68 (3), p.1191-1199
Hauptverfasser:	Connop, B. P., Boegman, R. J., Beninger, R. J., Jhamandas, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	7‐Nitroindazole Animals Biological and medical sciences Cholinergic toxicity Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dizocilpine Maleate - pharmacology Enzyme Inhibitors - pharmacology Indazoles - pharmacology Lamotrigine Male Malonate Malonates - poisoning Medical sciences Nerve Degeneration Neurology Neurons - drug effects Neurons - pathology Neuroprotective Agents - pharmacology Nitric oxide synthase Nitric Oxide Synthase - antagonists & inhibitors Nitroarginine - pharmacology Nω‐Nitro‐l‐arginine Parasympathetic Nervous System - drug effects Parasympathetic Nervous System - pathology Prosencephalon - drug effects Prosencephalon - pathology Rats Rats, Sprague-Dawley Triazines - pharmacology
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