Anti-tumor promoting effects of naphthoquinone derivatives on short term Epstein-Barr early antigen activation assay and in mouse skin carcinogenesis
In continuation of our studies of natural and synthetic products as cancer chemopreventive agents, we have examined a number of naphthoquinone derivatives including monomeric, dimeric and tetrameric naphthaquinones occurring in the Diospyros and other selected plant genera. Several synthetic naphtho...
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| Veröffentlicht in: | Cancer letters 1997-02, Vol.113 (1), p.47-53 |
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| container_title | Cancer letters |
| container_volume | 113 |
| creator | Kapadia, Govind J. Balasubramanian, Venkataraman Tokuda, Harukuni Konoshima, Takao Takasaki, Midori Koyama, Junko Tagahaya, Kiyoshi Nishino, Hoyoku |
| description | In continuation of our studies of natural and synthetic products as cancer chemopreventive agents, we have examined a number of naphthoquinone derivatives including monomeric, dimeric and tetrameric naphthaquinones occurring in the
Diospyros and other selected plant genera. Several synthetic naphthoquinones were also evaluated. Initially these compounds were tested for in vitro anti-tumor promoting effect on Epstein-Barr virus early antigen activation produced by the tumor promoter 12-
O-tetradecanoylphorbol-13-acetate (TPA) and thereafter in in vivo on two-stage mouse skin carcinogenesis. Our studies show some of these compounds have potent anti-tumor promoting activity. |
| doi_str_mv | 10.1016/S0304-3835(96)04582-X |
| format | Article |
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Diospyros and other selected plant genera. Several synthetic naphthoquinones were also evaluated. Initially these compounds were tested for in vitro anti-tumor promoting effect on Epstein-Barr virus early antigen activation produced by the tumor promoter 12-
O-tetradecanoylphorbol-13-acetate (TPA) and thereafter in in vivo on two-stage mouse skin carcinogenesis. Our studies show some of these compounds have potent anti-tumor promoting activity.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(96)04582-X</identifier><identifier>PMID: 9065800</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Antigens, Viral - drug effects ; Antigens, Viral - metabolism ; Biological and medical sciences ; Cancer inhibitory effect ; Carcinogenesis, carcinogens and anticarcinogens ; Carcinogens ; Cells, Cultured ; Chemical agents ; Epstein-Barr virus ; Female ; Medical sciences ; Mice ; Mice, Inbred ICR ; Naphthoquinone derivatives ; Naphthoquinones - pharmacology ; Papilloma - chemically induced ; Papilloma - prevention & control ; Skin Neoplasms - chemically induced ; Skin Neoplasms - prevention & control ; Tetradecanoylphorbol Acetate ; Tumors</subject><ispartof>Cancer letters, 1997-02, Vol.113 (1), p.47-53</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-85b0b1910a8de965b1085ad2255ce6394343b356454a4acbba71f05d4ffc59263</citedby><cites>FETCH-LOGICAL-c486t-85b0b1910a8de965b1085ad2255ce6394343b356454a4acbba71f05d4ffc59263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030438359604582X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2611368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9065800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kapadia, Govind J.</creatorcontrib><creatorcontrib>Balasubramanian, Venkataraman</creatorcontrib><creatorcontrib>Tokuda, Harukuni</creatorcontrib><creatorcontrib>Konoshima, Takao</creatorcontrib><creatorcontrib>Takasaki, Midori</creatorcontrib><creatorcontrib>Koyama, Junko</creatorcontrib><creatorcontrib>Tagahaya, Kiyoshi</creatorcontrib><creatorcontrib>Nishino, Hoyoku</creatorcontrib><title>Anti-tumor promoting effects of naphthoquinone derivatives on short term Epstein-Barr early antigen activation assay and in mouse skin carcinogenesis</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>In continuation of our studies of natural and synthetic products as cancer chemopreventive agents, we have examined a number of naphthoquinone derivatives including monomeric, dimeric and tetrameric naphthaquinones occurring in the
Diospyros and other selected plant genera. Several synthetic naphthoquinones were also evaluated. Initially these compounds were tested for in vitro anti-tumor promoting effect on Epstein-Barr virus early antigen activation produced by the tumor promoter 12-
O-tetradecanoylphorbol-13-acetate (TPA) and thereafter in in vivo on two-stage mouse skin carcinogenesis. Our studies show some of these compounds have potent anti-tumor promoting activity.</description><subject>Animals</subject><subject>Antigens, Viral - drug effects</subject><subject>Antigens, Viral - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cancer inhibitory effect</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Carcinogens</subject><subject>Cells, Cultured</subject><subject>Chemical agents</subject><subject>Epstein-Barr virus</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Naphthoquinone derivatives</subject><subject>Naphthoquinones - pharmacology</subject><subject>Papilloma - chemically induced</subject><subject>Papilloma - prevention & control</subject><subject>Skin Neoplasms - chemically induced</subject><subject>Skin Neoplasms - prevention & control</subject><subject>Tetradecanoylphorbol Acetate</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EKtPCI1TyAiFYBOzEdpwVKlULSJVYAFJ31o1z0zEk9tR2RuqD8L54fjRbVrZ0vnP_DiGXnH3gjKuPP1jDRNXoRr7r1HsmpK6r-2dkxXVbV22n2XOyOiEvyXlKvxljUrTyjJx1TEnN2Ir8vfLZVXmZQ6SbGOaQnX-gOI5oc6JhpB4267wOj4vzwSMdMLotZLfFonqa1iFmmjHO9GaTMjpffYYYKUKcniiU2g_oKdi8NxUDpAQ7YaDO0zksCWn6U74Woi0dCo3JpVfkxQhTwtfH94L8ur35ef21uvv-5dv11V1lhVa50rJnPe84Az1gp2TPmZYw1LWUFlXTiUY0fSOVkAIE2L6Hlo9MDmIcrexq1VyQt4e6ZfXHBVM2s0sWpwk8ltkMlx2XrG4LKA-gjSGliKPZRDdDfDKcmV0cZh-H2d3adMrs4zD3xXd5bLD0Mw4n1_H-RX9z1CFZmMYI3rp0wmrFeaN0wT4dMCzH2DqMJlmH3uLgYgnKDMH9Z5B_XAqqjg</recordid><startdate>19970226</startdate><enddate>19970226</enddate><creator>Kapadia, Govind J.</creator><creator>Balasubramanian, Venkataraman</creator><creator>Tokuda, Harukuni</creator><creator>Konoshima, Takao</creator><creator>Takasaki, Midori</creator><creator>Koyama, Junko</creator><creator>Tagahaya, Kiyoshi</creator><creator>Nishino, Hoyoku</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>19970226</creationdate><title>Anti-tumor promoting effects of naphthoquinone derivatives on short term Epstein-Barr early antigen activation assay and in mouse skin carcinogenesis</title><author>Kapadia, Govind J. ; Balasubramanian, Venkataraman ; Tokuda, Harukuni ; Konoshima, Takao ; Takasaki, Midori ; Koyama, Junko ; Tagahaya, Kiyoshi ; Nishino, Hoyoku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-85b0b1910a8de965b1085ad2255ce6394343b356454a4acbba71f05d4ffc59263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Antigens, Viral - drug effects</topic><topic>Antigens, Viral - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cancer inhibitory effect</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Carcinogens</topic><topic>Cells, Cultured</topic><topic>Chemical agents</topic><topic>Epstein-Barr virus</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Naphthoquinone derivatives</topic><topic>Naphthoquinones - pharmacology</topic><topic>Papilloma - chemically induced</topic><topic>Papilloma - prevention & control</topic><topic>Skin Neoplasms - chemically induced</topic><topic>Skin Neoplasms - prevention & control</topic><topic>Tetradecanoylphorbol Acetate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kapadia, Govind J.</creatorcontrib><creatorcontrib>Balasubramanian, Venkataraman</creatorcontrib><creatorcontrib>Tokuda, Harukuni</creatorcontrib><creatorcontrib>Konoshima, Takao</creatorcontrib><creatorcontrib>Takasaki, Midori</creatorcontrib><creatorcontrib>Koyama, Junko</creatorcontrib><creatorcontrib>Tagahaya, Kiyoshi</creatorcontrib><creatorcontrib>Nishino, Hoyoku</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kapadia, Govind J.</au><au>Balasubramanian, Venkataraman</au><au>Tokuda, Harukuni</au><au>Konoshima, Takao</au><au>Takasaki, Midori</au><au>Koyama, Junko</au><au>Tagahaya, Kiyoshi</au><au>Nishino, Hoyoku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-tumor promoting effects of naphthoquinone derivatives on short term Epstein-Barr early antigen activation assay and in mouse skin carcinogenesis</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1997-02-26</date><risdate>1997</risdate><volume>113</volume><issue>1</issue><spage>47</spage><epage>53</epage><pages>47-53</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>In continuation of our studies of natural and synthetic products as cancer chemopreventive agents, we have examined a number of naphthoquinone derivatives including monomeric, dimeric and tetrameric naphthaquinones occurring in the
Diospyros and other selected plant genera. Several synthetic naphthoquinones were also evaluated. Initially these compounds were tested for in vitro anti-tumor promoting effect on Epstein-Barr virus early antigen activation produced by the tumor promoter 12-
O-tetradecanoylphorbol-13-acetate (TPA) and thereafter in in vivo on two-stage mouse skin carcinogenesis. Our studies show some of these compounds have potent anti-tumor promoting activity.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9065800</pmid><doi>10.1016/S0304-3835(96)04582-X</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1997-02, Vol.113 (1), p.47-53 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15915027 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antigens, Viral - drug effects Antigens, Viral - metabolism Biological and medical sciences Cancer inhibitory effect Carcinogenesis, carcinogens and anticarcinogens Carcinogens Cells, Cultured Chemical agents Epstein-Barr virus Female Medical sciences Mice Mice, Inbred ICR Naphthoquinone derivatives Naphthoquinones - pharmacology Papilloma - chemically induced Papilloma - prevention & control Skin Neoplasms - chemically induced Skin Neoplasms - prevention & control Tetradecanoylphorbol Acetate Tumors |
| title | Anti-tumor promoting effects of naphthoquinone derivatives on short term Epstein-Barr early antigen activation assay and in mouse skin carcinogenesis |
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