Contribution of Ventral Tegmental Area Dopamine Neurons to Expression of Conditional Fear: Effects of Electrical Stimulation, Excitotoxin Lesions, and Quinpirole Infusion on Potentiated Startle in Rats
Potentiated startle was used in this study to determine the fear-motivational functions of the ventral tegmental area (VTA). In Experiment 1, electrical stimulation of the VTA increased acoustic startle amplitudes. In subsequent experiments fear-potentiated startle was assessed following axon-sparin...
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| Veröffentlicht in: | Behavioral neuroscience 1996-12, Vol.110 (6), p.1349-1364 |
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| creator | Borowski, Thomas B Kokkinidis, Larry |
| description | Potentiated startle was used in this study to determine the fear-motivational functions of the ventral tegmental area (VTA). In Experiment 1, electrical stimulation of the VTA increased acoustic startle amplitudes. In subsequent experiments fear-potentiated startle was assessed following axon-sparing
N
-methyl-
d
-aspartic acid (NMDA) lesions of the VTA and after bilateral intra-VTA infusion of the dopamine (DA) D
2/3
receptor agonist quinpirole. The NMDA lesions produced substantial cell loss in the medial ventral tegmentum and suppressed fear expression. Similarly, inhibition of DA neuronal activity associated with locally administered quinpirole blocked fear-potentiated startle. It was suggested that VTA neurons and their forebrain DA projections regulate levels of aversive emotional arousal within the amygdala-based fear system. |
| doi_str_mv | 10.1037/0735-7044.110.6.1349 |
| format | Article |
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N
-methyl-
d
-aspartic acid (NMDA) lesions of the VTA and after bilateral intra-VTA infusion of the dopamine (DA) D
2/3
receptor agonist quinpirole. The NMDA lesions produced substantial cell loss in the medial ventral tegmentum and suppressed fear expression. Similarly, inhibition of DA neuronal activity associated with locally administered quinpirole blocked fear-potentiated startle. It was suggested that VTA neurons and their forebrain DA projections regulate levels of aversive emotional arousal within the amygdala-based fear system.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.110.6.1349</identifier><identifier>PMID: 8986337</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Acoustic Stimulation ; Animal ; Animal Motivation ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Conditioning, Classical - drug effects ; Conditioning, Classical - physiology ; Dopamine ; Dopamine - pharmacology ; Dopamine - physiology ; Electric Stimulation ; Electrical Stimulation ; Fear ; Fear & phobias ; Fear - drug effects ; Fear - physiology ; Fundamental and applied biological sciences. Psychology ; Male ; N-Methylaspartate - pharmacology ; Neural Pathways - physiology ; Neurology ; Neurons ; Neurotoxins - pharmacology ; Neurotransmission and behavior ; Prosencephalon - physiology ; Psychology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Quinpirole ; Quinpirole - pharmacology ; Rats ; Reflex, Startle - drug effects ; Reflex, Startle - physiology ; Rodents ; Startle Reflex ; Tegmentum ; Ventral Tegmental Area - drug effects ; Ventral Tegmental Area - physiology</subject><ispartof>Behavioral neuroscience, 1996-12, Vol.110 (6), p.1349-1364</ispartof><rights>1996 American Psychological Association</rights><rights>1997 INIST-CNRS</rights><rights>Copyright American Psychological Association Dec 1996</rights><rights>1996, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2525194$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8986337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borowski, Thomas B</creatorcontrib><creatorcontrib>Kokkinidis, Larry</creatorcontrib><title>Contribution of Ventral Tegmental Area Dopamine Neurons to Expression of Conditional Fear: Effects of Electrical Stimulation, Excitotoxin Lesions, and Quinpirole Infusion on Potentiated Startle in Rats</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Potentiated startle was used in this study to determine the fear-motivational functions of the ventral tegmental area (VTA). In Experiment 1, electrical stimulation of the VTA increased acoustic startle amplitudes. In subsequent experiments fear-potentiated startle was assessed following axon-sparing
N
-methyl-
d
-aspartic acid (NMDA) lesions of the VTA and after bilateral intra-VTA infusion of the dopamine (DA) D
2/3
receptor agonist quinpirole. The NMDA lesions produced substantial cell loss in the medial ventral tegmentum and suppressed fear expression. Similarly, inhibition of DA neuronal activity associated with locally administered quinpirole blocked fear-potentiated startle. It was suggested that VTA neurons and their forebrain DA projections regulate levels of aversive emotional arousal within the amygdala-based fear system.</description><subject>Acoustic Stimulation</subject><subject>Animal</subject><subject>Animal Motivation</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Conditioning, Classical - drug effects</subject><subject>Conditioning, Classical - physiology</subject><subject>Dopamine</subject><subject>Dopamine - pharmacology</subject><subject>Dopamine - physiology</subject><subject>Electric Stimulation</subject><subject>Electrical Stimulation</subject><subject>Fear</subject><subject>Fear & phobias</subject><subject>Fear - drug effects</subject><subject>Fear - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>N-Methylaspartate - pharmacology</subject><subject>Neural Pathways - physiology</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neurotoxins - pharmacology</subject><subject>Neurotransmission and behavior</subject><subject>Prosencephalon - physiology</subject><subject>Psychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Quinpirole</subject><subject>Quinpirole - pharmacology</subject><subject>Rats</subject><subject>Reflex, Startle - drug effects</subject><subject>Reflex, Startle - physiology</subject><subject>Rodents</subject><subject>Startle Reflex</subject><subject>Tegmentum</subject><subject>Ventral Tegmental Area - drug effects</subject><subject>Ventral Tegmental Area - physiology</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS1EVS6FNwApQohdLuO_OF5Wty1UqsqmILGybGeCUiVxsBOJvj0OjS6IRVcee75zbM8h5A2FPQWuPoLislQgxJ7mo2pPudDPyI5qrkuAWjwnuyPygrxM6R4ABAh5Sk5rXVecqx35fgjjHDu3zF0Yi9AW3zDvbV_c4Y8hl7k6j2iLizDZoRuxuMUlhjEVcyguf00RU9qE2ajpVpcsuUIbX5GT1vYJX2_rGfl6dXl3-FzefPl0fTi_KS3X1VxKYE1FQUuGlkFLJTRSClAOZI1UKNV43TLtnLfKM4bC25aDU66phHO15Wfkw6PvFMPPBdNshi557Hs7YliSoVJToSXN4Lv_wPuwxPzcZCoqOP8zkycgBryuaS1EhsQj5GNIKWJrptgNNj4YCmbNxqyDN-vgTc7GVGbNJsvebt6LG7A5irYwcv_91rfJ276NdvRdOmJMMkm1-PthO1kzpQdv49z5HpNxI_57329VFKIT</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Borowski, Thomas B</creator><creator>Kokkinidis, Larry</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope></search><sort><creationdate>19961201</creationdate><title>Contribution of Ventral Tegmental Area Dopamine Neurons to Expression of Conditional Fear</title><author>Borowski, Thomas B ; Kokkinidis, Larry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a396t-502d610952ea20f150d55407b058e1477dc9f29bbca7c22e4caf30b7bd64bb8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acoustic Stimulation</topic><topic>Animal</topic><topic>Animal Motivation</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Conditioning, Classical - drug effects</topic><topic>Conditioning, Classical - physiology</topic><topic>Dopamine</topic><topic>Dopamine - pharmacology</topic><topic>Dopamine - physiology</topic><topic>Electric Stimulation</topic><topic>Electrical Stimulation</topic><topic>Fear</topic><topic>Fear & phobias</topic><topic>Fear - drug effects</topic><topic>Fear - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>N-Methylaspartate - pharmacology</topic><topic>Neural Pathways - physiology</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neurotoxins - pharmacology</topic><topic>Neurotransmission and behavior</topic><topic>Prosencephalon - physiology</topic><topic>Psychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Quinpirole</topic><topic>Quinpirole - pharmacology</topic><topic>Rats</topic><topic>Reflex, Startle - drug effects</topic><topic>Reflex, Startle - physiology</topic><topic>Rodents</topic><topic>Startle Reflex</topic><topic>Tegmentum</topic><topic>Ventral Tegmental Area - drug effects</topic><topic>Ventral Tegmental Area - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borowski, Thomas B</creatorcontrib><creatorcontrib>Kokkinidis, Larry</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borowski, Thomas B</au><au>Kokkinidis, Larry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of Ventral Tegmental Area Dopamine Neurons to Expression of Conditional Fear: Effects of Electrical Stimulation, Excitotoxin Lesions, and Quinpirole Infusion on Potentiated Startle in Rats</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>110</volume><issue>6</issue><spage>1349</spage><epage>1364</epage><pages>1349-1364</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>Potentiated startle was used in this study to determine the fear-motivational functions of the ventral tegmental area (VTA). In Experiment 1, electrical stimulation of the VTA increased acoustic startle amplitudes. In subsequent experiments fear-potentiated startle was assessed following axon-sparing
N
-methyl-
d
-aspartic acid (NMDA) lesions of the VTA and after bilateral intra-VTA infusion of the dopamine (DA) D
2/3
receptor agonist quinpirole. The NMDA lesions produced substantial cell loss in the medial ventral tegmentum and suppressed fear expression. Similarly, inhibition of DA neuronal activity associated with locally administered quinpirole blocked fear-potentiated startle. It was suggested that VTA neurons and their forebrain DA projections regulate levels of aversive emotional arousal within the amygdala-based fear system.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>8986337</pmid><doi>10.1037/0735-7044.110.6.1349</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Behavioral neuroscience, 1996-12, Vol.110 (6), p.1349-1364 |
| issn | 0735-7044 1939-0084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15914951 |
| source | MEDLINE; EBSCOhost APA PsycARTICLES |
| subjects | Acoustic Stimulation Animal Animal Motivation Animals Behavioral psychophysiology Biological and medical sciences Conditioning, Classical - drug effects Conditioning, Classical - physiology Dopamine Dopamine - pharmacology Dopamine - physiology Electric Stimulation Electrical Stimulation Fear Fear & phobias Fear - drug effects Fear - physiology Fundamental and applied biological sciences. Psychology Male N-Methylaspartate - pharmacology Neural Pathways - physiology Neurology Neurons Neurotoxins - pharmacology Neurotransmission and behavior Prosencephalon - physiology Psychology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Quinpirole Quinpirole - pharmacology Rats Reflex, Startle - drug effects Reflex, Startle - physiology Rodents Startle Reflex Tegmentum Ventral Tegmental Area - drug effects Ventral Tegmental Area - physiology |
| title | Contribution of Ventral Tegmental Area Dopamine Neurons to Expression of Conditional Fear: Effects of Electrical Stimulation, Excitotoxin Lesions, and Quinpirole Infusion on Potentiated Startle in Rats |
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