Leptin receptor (OB-R) signaling: cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization

The leptin receptor (OB-R) mediates the weight regulatory effects of the adipocyte secreted hormone leptin (OB). Previously we have shown that the long form of OB-R, expressed predominantly in the hypothalamus, can mediate ligand-induced activation of signal transducer and activator of transcription...

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Veröffentlicht in:	The Journal of biological chemistry 1997-02, Vol.272 (7), p.4065-4071
Hauptverfasser:	White, D.W. (Millennium Pharmaceuticals, Cambridge, MA.), Kuropatwinski, K.K, Devos, R, Baumann, H, Tartaglia, L.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line CHIMIORECEPTEUR CITOQUINAS CITOQUININAS COS Cells CYTOKINE CYTOKININE Cytoplasm - metabolism EXPRESION GENICA EXPRESSION DES GENES GENE GENERO HUMANO GENES GENETICA GENETIQUE GENRE HUMAIN HORMONAS HORMONE MUTACION MUTACION INDUCIDA Mutagenesis MUTANT MUTANTES MUTATION MUTATION PROVOQUEE PROTEINAS PROTEINE QUIMIORECEPTORES RECEPTEUR D'HORMONE RECEPTORES DE HORMONAS Receptors, Cell Surface Receptors, Granulocyte Colony-Stimulating Factor - genetics Receptors, Granulocyte Colony-Stimulating Factor - metabolism Receptors, Leptin Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Signal Transduction TRANSCRIPCION TRANSCRIPTION
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