Pharmacokinetics of remikiren, a potent orally active inhibitor of human renin, in rat, dog and primates

1. An hplc method with fluorescence derivatization was developed for the quantification of remikiren in plasma (limit of quantification 2 ng/ml). This was used to determine the pharmacokinetics in various species of primate, in which the compound is a potent inhibitor of renin, as well as in the rat...

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