Numerical and structural chromosome aberrations induced by etoposide (VP16) during oocyte maturation of mice: transmission to one-cell zygotes and damage to dictyate oocytes

The antineoplastic drug etoposide (ET) inhibits topoisomerase II (topo II) activity by forming a ternary complex (DNA–ET–topo II). This complex prevents the DNA-strandrejoining activity of topo II and may result in structural chromosome aberrations. Inhibition of topo II activity may also predispose...

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Veröffentlicht in:	Mutagenesis 1996-07, Vol.11 (4), p.357-361
Hauptverfasser:	Mailhes, John B., Marchetti, Francesco, Young, Daniel, London, S.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy Animals Antineoplastic Agents, Phytogenic - toxicity Biological and medical sciences Chemical mutagenesis Chromosome Aberrations Etoposide - toxicity Female Humans Male Medical sciences Mice Mice, Inbred ICR Mutagens - toxicity Oocytes - drug effects Oocytes - growth & development Toxicology Zygote - drug effects
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