Inhibition of DNA synthesis by paracetamol in different tissues of the rat in vivo

DNA synthesis in the spleen, testis, thymus, stomach, small intestine and bone marrow was inhibited by 70–90% at 1 h following an oral dose of paracetamol (1 g/kg). This inhibitory effect was still apparent using a lower dose of 125 mg/kg paracetamol, but not when the dose was reduced to 60 mg/kg. I...

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