Synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid by human monocytes and lymphocytes

We recently demonstrated that the arachidonate metabolite 5(S)‐hydroxy‐6,8,11,14‐eicosatetraenoic acid (5‐HETE) is converted by a highly specific dehydrogenase in human neutrophils to 5‐oxo‐6,8,11,14‐eicosatetraenoic acid (5‐oxo‐ETE), which is a potent stimulator of these cells. The objective of thi...

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Veröffentlicht in:	Journal of leukocyte biology 1996-06, Vol.59 (6), p.847-854
Hauptverfasser:	Zhang, Ying, Styhler, Angela, Powell, William S.
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐HETE Alcohol Oxidoreductases - metabolism Calcimycin - pharmacology dehydrogenase Dose-Response Relationship, Drug eicosanoids Humans Hydroxyeicosatetraenoic Acids - biosynthesis leukotriene B 4 Lymphocytes - metabolism Monocytes - metabolism neutrophils Neutrophils - enzymology phorbol myristate acetate Tetradecanoylphorbol Acetate - pharmacology
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