Activation of chromium(VI) by thiols results in chromium(V) formation, chromium binding to DNA and altered DNA conformation

The ability of the thiols glutathione, cysteine, β-mercaptoethanol and dithiothreitol to effect chromluin(VI)-induced DNA damage in vitro has been investigated. Reaction of pBR322 DNA with chromium(VI) in the presence of the thiols led to formation of chromlum(V) and chromium-DNA adducts. The extent...

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Veröffentlicht in:	Carcinogenesis (New York) 1991-04, Vol.12 (4), p.551-561
Hauptverfasser:	Borges, Kim M., Boswell, John S., Liebross, Robert H., Wetterhahn, Karen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Chromium - metabolism Cysteine - pharmacology Dithiothreitol - pharmacology DNA - metabolism DNA Damage Electron Spin Resonance Spectroscopy Electrophoresis, Agar Gel Glutathione - pharmacology Medical sciences Mercaptoethanol - pharmacology Microscopy, Electron Nucleic Acid Conformation Oxidation-Reduction Plasmids Spectrum Analysis - methods Sulfhydryl Compounds - metabolism Tumors
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