Chromosomal characteristics of chronic and blastic phase of chronic myeloid leukemia. A study of 100 patients in India

Chromosomal characteristics of chronic and blastic phase of chronic myeloid leukemia. A study of 100 patients in India

We report the cytogenetic findings of 100 patients with chronic myeloid leukemia (CML) (72 patients in chronic phase (CP) and 28 patients in blastic phase (BP)). Of the 95 Ph + patients, six had Ph variant translocations involving chromosomes 1, 6, 7, 10, and 12. The percentage frequency of patients...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer genetics and cytogenetics 1991-01, Vol.41 (2), p.167-181
Hauptverfasser: Kadam, PR, Najangud, G J, Advani, SH, Nair, C, Banavali, R, Gopal, R, Saikia, T
Format: Artikel
Sprache:eng
Schlagworte:
myeloid leukemia
philadelphia chromosome
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 181
container_issue 2
container_start_page 167
container_title Cancer genetics and cytogenetics
container_volume 41
creator Kadam, PR
Najangud, G J
Advani, SH
Nair, C
Banavali, R
Gopal, R
Saikia, T
description We report the cytogenetic findings of 100 patients with chronic myeloid leukemia (CML) (72 patients in chronic phase (CP) and 28 patients in blastic phase (BP)). Of the 95 Ph + patients, six had Ph variant translocations involving chromosomes 1, 6, 7, 10, and 12. The percentage frequency of patients with chromosomal changes other than Ph was 7.3%. The additional aberrations (e.g, +Ph, +8, i(17q), and +19 were observed in 66.6% of BP patients. Of these anomalies, the frequency of +Ph and +19 was higher in our patients than the incidence reported in literature. The association of +Ph and +19 in patients with extramedullary T-cell blast crisis is an unusual finding as compared with reports in the literature and could be explained by geographic heterogeneity.
format Article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_15903332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15903332</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_159033323</originalsourceid><addsrcrecordid>eNqNij0PAUEQQLcg8fkfptKRPcehFCH0ehl7Izfsx9nZk_j3SBRK1Uveey3V1VkxH88KveyonshVa72YroquemyqGFyQ4NCCqTCiSRRZEhuBcHmrGDwbQF_C2eLHQ12h0G90T7KBS7DU3MgxTmANkpry-ZkyraHGxOSTAHs4-JJxoNoXtELDL_tqtNseN_txHcO9IUknx2LIWvQUGjll85XO83ya_z2-ABKwTt0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15903332</pqid></control><display><type>article</type><title>Chromosomal characteristics of chronic and blastic phase of chronic myeloid leukemia. A study of 100 patients in India</title><source>Access via ScienceDirect (Elsevier)</source><creator>Kadam, PR ; Najangud, G J ; Advani, SH ; Nair, C ; Banavali, R ; Gopal, R ; Saikia, T</creator><creatorcontrib>Kadam, PR ; Najangud, G J ; Advani, SH ; Nair, C ; Banavali, R ; Gopal, R ; Saikia, T</creatorcontrib><description>We report the cytogenetic findings of 100 patients with chronic myeloid leukemia (CML) (72 patients in chronic phase (CP) and 28 patients in blastic phase (BP)). Of the 95 Ph + patients, six had Ph variant translocations involving chromosomes 1, 6, 7, 10, and 12. The percentage frequency of patients with chromosomal changes other than Ph was 7.3%. The additional aberrations (e.g, +Ph, +8, i(17q), and +19 were observed in 66.6% of BP patients. Of these anomalies, the frequency of +Ph and +19 was higher in our patients than the incidence reported in literature. The association of +Ph and +19 in patients with extramedullary T-cell blast crisis is an unusual finding as compared with reports in the literature and could be explained by geographic heterogeneity.</description><identifier>ISSN: 0165-4608</identifier><language>eng</language><subject>myeloid leukemia ; philadelphia chromosome</subject><ispartof>Cancer genetics and cytogenetics, 1991-01, Vol.41 (2), p.167-181</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Kadam, PR</creatorcontrib><creatorcontrib>Najangud, G J</creatorcontrib><creatorcontrib>Advani, SH</creatorcontrib><creatorcontrib>Nair, C</creatorcontrib><creatorcontrib>Banavali, R</creatorcontrib><creatorcontrib>Gopal, R</creatorcontrib><creatorcontrib>Saikia, T</creatorcontrib><title>Chromosomal characteristics of chronic and blastic phase of chronic myeloid leukemia. A study of 100 patients in India</title><title>Cancer genetics and cytogenetics</title><description>We report the cytogenetic findings of 100 patients with chronic myeloid leukemia (CML) (72 patients in chronic phase (CP) and 28 patients in blastic phase (BP)). Of the 95 Ph + patients, six had Ph variant translocations involving chromosomes 1, 6, 7, 10, and 12. The percentage frequency of patients with chromosomal changes other than Ph was 7.3%. The additional aberrations (e.g, +Ph, +8, i(17q), and +19 were observed in 66.6% of BP patients. Of these anomalies, the frequency of +Ph and +19 was higher in our patients than the incidence reported in literature. The association of +Ph and +19 in patients with extramedullary T-cell blast crisis is an unusual finding as compared with reports in the literature and could be explained by geographic heterogeneity.</description><subject>myeloid leukemia</subject><subject>philadelphia chromosome</subject><issn>0165-4608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNqNij0PAUEQQLcg8fkfptKRPcehFCH0ehl7Izfsx9nZk_j3SBRK1Uveey3V1VkxH88KveyonshVa72YroquemyqGFyQ4NCCqTCiSRRZEhuBcHmrGDwbQF_C2eLHQ12h0G90T7KBS7DU3MgxTmANkpry-ZkyraHGxOSTAHs4-JJxoNoXtELDL_tqtNseN_txHcO9IUknx2LIWvQUGjll85XO83ya_z2-ABKwTt0</recordid><startdate>19910101</startdate><enddate>19910101</enddate><creator>Kadam, PR</creator><creator>Najangud, G J</creator><creator>Advani, SH</creator><creator>Nair, C</creator><creator>Banavali, R</creator><creator>Gopal, R</creator><creator>Saikia, T</creator><scope>7T3</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19910101</creationdate><title>Chromosomal characteristics of chronic and blastic phase of chronic myeloid leukemia. A study of 100 patients in India</title><author>Kadam, PR ; Najangud, G J ; Advani, SH ; Nair, C ; Banavali, R ; Gopal, R ; Saikia, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_159033323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>myeloid leukemia</topic><topic>philadelphia chromosome</topic><toplevel>online_resources</toplevel><creatorcontrib>Kadam, PR</creatorcontrib><creatorcontrib>Najangud, G J</creatorcontrib><creatorcontrib>Advani, SH</creatorcontrib><creatorcontrib>Nair, C</creatorcontrib><creatorcontrib>Banavali, R</creatorcontrib><creatorcontrib>Gopal, R</creatorcontrib><creatorcontrib>Saikia, T</creatorcontrib><collection>Human Genome Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kadam, PR</au><au>Najangud, G J</au><au>Advani, SH</au><au>Nair, C</au><au>Banavali, R</au><au>Gopal, R</au><au>Saikia, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosomal characteristics of chronic and blastic phase of chronic myeloid leukemia. A study of 100 patients in India</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><date>1991-01-01</date><risdate>1991</risdate><volume>41</volume><issue>2</issue><spage>167</spage><epage>181</epage><pages>167-181</pages><issn>0165-4608</issn><abstract>We report the cytogenetic findings of 100 patients with chronic myeloid leukemia (CML) (72 patients in chronic phase (CP) and 28 patients in blastic phase (BP)). Of the 95 Ph + patients, six had Ph variant translocations involving chromosomes 1, 6, 7, 10, and 12. The percentage frequency of patients with chromosomal changes other than Ph was 7.3%. The additional aberrations (e.g, +Ph, +8, i(17q), and +19 were observed in 66.6% of BP patients. Of these anomalies, the frequency of +Ph and +19 was higher in our patients than the incidence reported in literature. The association of +Ph and +19 in patients with extramedullary T-cell blast crisis is an unusual finding as compared with reports in the literature and could be explained by geographic heterogeneity.</abstract></addata></record>
fulltext fulltext
identifier ISSN: 0165-4608
ispartof Cancer genetics and cytogenetics, 1991-01, Vol.41 (2), p.167-181
issn 0165-4608
language eng
recordid cdi_proquest_miscellaneous_15903332
source Access via ScienceDirect (Elsevier)
subjects myeloid leukemia
philadelphia chromosome
title Chromosomal characteristics of chronic and blastic phase of chronic myeloid leukemia. A study of 100 patients in India
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T21%3A47%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chromosomal%20characteristics%20of%20chronic%20and%20blastic%20phase%20of%20chronic%20myeloid%20leukemia.%20A%20study%20of%20100%20patients%20in%20India&rft.jtitle=Cancer%20genetics%20and%20cytogenetics&rft.au=Kadam,%20PR&rft.date=1991-01-01&rft.volume=41&rft.issue=2&rft.spage=167&rft.epage=181&rft.pages=167-181&rft.issn=0165-4608&rft_id=info:doi/&rft_dat=%3Cproquest%3E15903332%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15903332&rft_id=info:pmid/&rfr_iscdi=true