All-Trans-Retinoic Acid in Maternal Plasma and Teratogenicity in Rats and Rabbits

The teratogenicity of all-trans-retinoic acid, 13-cis-retinoic acid, and retinol was investigated in pregnant Wistar rats given a single oral dose on Day 10 of gestation. External malformations showed dose-dependent increases and the order of potency was all-trans-retinoic acid > retinol > 13-...

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Veröffentlicht in:	Toxicology and applied pharmacology 1996-12, Vol.141 (2), p.456-472
Hauptverfasser:	Tembe, E.A., Honeywell, R., Buss, N.E., Renwick, A.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced Animals Biological and medical sciences BLOOD PLASMA CONEJO (ORYCTOLAGUS) DOSAGE DOSIFICACION Drug toxicity and drugs side effects treatment FARMACOLOGIA Female FETO FOETUS GENETIC DISORDERS GESTACION GESTATION Glucuronates - metabolism ISOMERS LAPIN (ORYCTOLAGUS) MADRE Male Medical sciences MERE METABOLITE METABOLITES METABOLITOS Miscellaneous (drug allergy, mutagens, teratogens...) MOTHERS PHARMACOLOGIE PHARMACOLOGY Pharmacology. Drug treatments PLASMA SANGUIN PLASMA SANGUINEO PREGNANCY Pregnancy, Animal - metabolism RABBITS RAT RATA RATS Rats, Wistar Receptors, Retinoic Acid - genetics RETINOL RNA, Messenger - analysis TERATOGENESIS TOXICIDAD TOXICITE TOXICITY TRASTORNOS GENETICOS Tretinoin - administration & dosage Tretinoin - pharmacokinetics Tretinoin - toxicity TROUBLE GENETIQUE
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