Effect of vitamin E deficiency and/or oral female sex hormones on aortic connective tissue components in female rat
A vitamin E (VE)-deficient diet and/or oral female sex hormones (OFH) were given for a period of 120 days to female rats, during which time the changes in the contents of aortic collagen, elastin and glycosaminoglycans (GAG) derived from the proteoglycans were investigated. The VE-deficient diet alo...
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| Veröffentlicht in: | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 1990/10/05, Vol.31(5), pp.409-413_1 |
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| container_end_page | 413_1 |
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| container_title | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) |
| container_volume | 31 |
| creator | Takahashi, N. (Tokyo Univ. of Agriculture (Japan)) Iwama, M Matsumoto, H Iitoi, Y Kanke, Y |
| description | A vitamin E (VE)-deficient diet and/or oral female sex hormones (OFH) were given for a period of 120 days to female rats, during which time the changes in the contents of aortic collagen, elastin and glycosaminoglycans (GAG) derived from the proteoglycans were investigated. The VE-deficient diet alone did not affect any of the parameters studied. The administration of OFH in VE sufficiency tended to increase all three component levels. The treatment with OFH under VE deficiency did not change the collagen and elastin levels, whereas it tended to decrease the contents of GAG, some of which have been known to have an anticoagulant and platelet aggregation-inhibitory activities. Thus, these observations might suggest that a poor VE status during intake of some xenobiotics such as OFH could be implicated in the pathogenesis of atherosclerotic cardiovascular disease. |
| doi_str_mv | 10.3358/shokueishi.31.409 |
| format | Article |
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The treatment with OFH under VE deficiency did not change the collagen and elastin levels, whereas it tended to decrease the contents of GAG, some of which have been known to have an anticoagulant and platelet aggregation-inhibitory activities. 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(Tokyo Univ. of Agriculture (Japan))</creatorcontrib><creatorcontrib>Iwama, M</creatorcontrib><creatorcontrib>Matsumoto, H</creatorcontrib><creatorcontrib>Iitoi, Y</creatorcontrib><creatorcontrib>Kanke, Y</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, N. (Tokyo Univ. of Agriculture (Japan))</au><au>Iwama, M</au><au>Matsumoto, H</au><au>Iitoi, Y</au><au>Kanke, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vitamin E deficiency and/or oral female sex hormones on aortic connective tissue components in female rat</atitle><jtitle>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)</jtitle><addtitle>Food Hyg. Saf. Sci.</addtitle><date>1990</date><risdate>1990</risdate><volume>31</volume><issue>5</issue><spage>409</spage><epage>413_1</epage><pages>409-413_1</pages><issn>0015-6426</issn><eissn>1882-1006</eissn><abstract>A vitamin E (VE)-deficient diet and/or oral female sex hormones (OFH) were given for a period of 120 days to female rats, during which time the changes in the contents of aortic collagen, elastin and glycosaminoglycans (GAG) derived from the proteoglycans were investigated. The VE-deficient diet alone did not affect any of the parameters studied. The administration of OFH in VE sufficiency tended to increase all three component levels. The treatment with OFH under VE deficiency did not change the collagen and elastin levels, whereas it tended to decrease the contents of GAG, some of which have been known to have an anticoagulant and platelet aggregation-inhibitory activities. Thus, these observations might suggest that a poor VE status during intake of some xenobiotics such as OFH could be implicated in the pathogenesis of atherosclerotic cardiovascular disease.</abstract><pub>Japanese Society for Food Hygiene and Safety</pub><doi>10.3358/shokueishi.31.409</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0015-6426 |
| ispartof | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 1990/10/05, Vol.31(5), pp.409-413_1 |
| issn | 0015-6426 1882-1006 |
| language | eng ; jpn |
| recordid | cdi_proquest_miscellaneous_15894491 |
| source | EZB-FREE-00999 freely available EZB journals |
| subjects | ANTICOAGULANT ANTICOAGULANTES ANTICOAGULANTS CARDIOVASCULAR SYSTEM COLAGENOS COLLAGEN COLLAGENE connective tissue of aorta elastin female rat GLICOSAMINOGLICANOS GLYCOSAMINOGLYCANE GLYCOSAMINOGLYCANS HORMONAS SEXUALES HORMONE SEXUELLE oral female sex hormones PLATELETS RAT RATA RATS SEX HORMONES SISTEMA CARDIOVASCULAR SYSTEME CARDIOVASCULAIRE THROMBOCYTE TROMBOCITOS VITAMIN E vitamin E deficiency VITAMINA E VITAMINE E |
| title | Effect of vitamin E deficiency and/or oral female sex hormones on aortic connective tissue components in female rat |
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