Antiserum to activity-dependent neurotrophic factor produces neuronal cell death in CNS cultures: immunological and biological specificity

Activity-dependent neurotrophic factor (ADNF) is a glia-derived protein that is neuroprotective at femtomolar concentrations. ADNF is released from astroglia after treatment with 0.1 nM vasoactive intestinal peptide (VIP). To further assess the biological role of ADNF, antiserum was produced followi...

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Veröffentlicht in:	Brain research. Developmental brain research 1997-04, Vol.99 (2), p.167-175
Hauptverfasser:	Gozes, Illana, Davidson, Ariane, Gozes, Yehoshua, Mascolo, Richard, Barth, Rolf, Warren, Dale, Hauser, Janet, Brenneman, Douglas E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies - pharmacology Antigen-Antibody Reactions Apoptosis Astrocytes - chemistry Astrocytes - cytology Astrocytes - enzymology Astroglia Binding Sites, Antibody Cell Death - immunology Cells, Cultured Cerebral cortex Cerebral Cortex - cytology Choline O-Acetyltransferase - metabolism Dose-Response Relationship, Immunologic Epitopes - chemistry Epitopes - immunology Growth Substances - pharmacology Mice Mice, Inbred BALB C Molecular Sequence Data Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - immunology Nerve Tissue Proteins - pharmacology Neurons - chemistry Neurons - cytology Neurons - enzymology Neuropeptides Neuroprotective Agents - chemistry Neuroprotective Agents - immunology Neuroprotective Agents - pharmacology Neurotoxins - toxicity Neurotrophic factor neurotrophin Oligopeptides Peptide Fragments - immunology Peptide Fragments - pharmacology Rats Spinal Cord - cytology Tetrodotoxin - toxicity Vasoactive intestinal peptide
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