Regional GABA-stimulated chloride uptake in amygdala kindled rats
γ-Aminobutyric acid (GABA)-stimulated 36chloride (Cl −) influx into membrane vesicles derived from cerebral cortex, hippocampus, cerebellum and midbrain/brainstem was evaluated in naive rats and amygdala or sham kindled rats. GABA-stimulated 36Cl − uptake was greatest in cortex and hippocampus of na...
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| Veröffentlicht in: | Neuroscience letters 1991-02, Vol.123 (2), p.269-272 |
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| container_title | Neuroscience letters |
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| creator | Tietz, Elizabeth I. Chiu, Ted H. |
| description | γ-Aminobutyric acid (GABA)-stimulated
36chloride (Cl
−) influx into membrane vesicles derived from cerebral cortex, hippocampus, cerebellum and midbrain/brainstem was evaluated in naive rats and amygdala or sham kindled rats. GABA-stimulated
36Cl
− uptake was greatest in cortex and hippocampus of naive rats. One week after amygdala kindling, 10 μM GABA-stimulated
36Cl
− influx was significantly reduced in each brain region, except midbrain/brainstem, indicating a regional variation in impaired GABAergic function. Midazolam potentiation of GABA-mediated Cl
− flux showed a regional variation. The effect of midazolam in kindled rats indicated either an increase in efficiency of GABA/benzodiazepine coupling in areas of reduced GABA function or its ability to restore Cl
− channel function to the pre-kindled state. |
| doi_str_mv | 10.1016/0304-3940(91)90948-S |
| format | Article |
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36chloride (Cl
−) influx into membrane vesicles derived from cerebral cortex, hippocampus, cerebellum and midbrain/brainstem was evaluated in naive rats and amygdala or sham kindled rats. GABA-stimulated
36Cl
− uptake was greatest in cortex and hippocampus of naive rats. One week after amygdala kindling, 10 μM GABA-stimulated
36Cl
− influx was significantly reduced in each brain region, except midbrain/brainstem, indicating a regional variation in impaired GABAergic function. Midazolam potentiation of GABA-mediated Cl
− flux showed a regional variation. The effect of midazolam in kindled rats indicated either an increase in efficiency of GABA/benzodiazepine coupling in areas of reduced GABA function or its ability to restore Cl
− channel function to the pre-kindled state.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(91)90948-S</identifier><identifier>PMID: 2027542</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Amygdala - physiology ; Animals ; Benzodiazepine ; Biological and medical sciences ; Brain - metabolism ; Brainstem ; Cerebellum ; Cerebral cortex ; Chloride flux ; Chlorides - pharmacokinetics ; Chlorine ; Drug Synergism ; gamma-Aminobutyric Acid - pharmacology ; Hippocampus ; Kindling ; Kindling, Neurologic ; Male ; Medical sciences ; Midazolam - pharmacology ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Radioisotopes ; Rats ; Rats, Inbred Strains ; Tissue Distribution ; γ-Aminobutyric acid (GABA)</subject><ispartof>Neuroscience letters, 1991-02, Vol.123 (2), p.269-272</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-eecec1bdfc5702982421f8d43ea791f3c729972c40c05047af1d1364934915073</citedby><cites>FETCH-LOGICAL-c469t-eecec1bdfc5702982421f8d43ea791f3c729972c40c05047af1d1364934915073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(91)90948-S$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19672561$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2027542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tietz, Elizabeth I.</creatorcontrib><creatorcontrib>Chiu, Ted H.</creatorcontrib><title>Regional GABA-stimulated chloride uptake in amygdala kindled rats</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>γ-Aminobutyric acid (GABA)-stimulated
36chloride (Cl
−) influx into membrane vesicles derived from cerebral cortex, hippocampus, cerebellum and midbrain/brainstem was evaluated in naive rats and amygdala or sham kindled rats. GABA-stimulated
36Cl
− uptake was greatest in cortex and hippocampus of naive rats. One week after amygdala kindling, 10 μM GABA-stimulated
36Cl
− influx was significantly reduced in each brain region, except midbrain/brainstem, indicating a regional variation in impaired GABAergic function. Midazolam potentiation of GABA-mediated Cl
− flux showed a regional variation. The effect of midazolam in kindled rats indicated either an increase in efficiency of GABA/benzodiazepine coupling in areas of reduced GABA function or its ability to restore Cl
− channel function to the pre-kindled state.</description><subject>Amygdala - physiology</subject><subject>Animals</subject><subject>Benzodiazepine</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brainstem</subject><subject>Cerebellum</subject><subject>Cerebral cortex</subject><subject>Chloride flux</subject><subject>Chlorides - pharmacokinetics</subject><subject>Chlorine</subject><subject>Drug Synergism</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>Hippocampus</subject><subject>Kindling</subject><subject>Kindling, Neurologic</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Midazolam - pharmacology</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Radioisotopes</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Tissue Distribution</subject><subject>γ-Aminobutyric acid (GABA)</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoOj7-gUI3ii6quWnaNBthFB0FQfCxDpnkdoym7Zi0wvx7O86gO1d3cb5zuHyEHAI9BwrFBc0oTzPJ6amEM0klL9PnDTKCUrBUSME2yegX2SG7Mb5TSnPI-TbZZpSJnLMRGT_hzLWN9slkfDVOY-fq3usObWLefBucxaSfd_oDE9ckul7MrPY6-XCN9QMTdBf3yValfcSD9d0jr7c3L9d36cPj5P56_JAaXsguRTRoYGorkwvKZMk4g6q0PEMtJFSZEUwOTxtODc0pF7oCC1nBZcYl5FRke-RktTsP7WePsVO1iwa91w22fVSQlzIDWQwgX4EmtDEGrNQ8uFqHhQKqlubUUotaalES1I859TzUjtb7_bRG-1taqxry43Wuo9G-CroxLv5ty0KwvICBu1xxOMj4chhUNA4bg9YFNJ2yrfv_kW_cl4hp</recordid><startdate>19910225</startdate><enddate>19910225</enddate><creator>Tietz, Elizabeth I.</creator><creator>Chiu, Ted H.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19910225</creationdate><title>Regional GABA-stimulated chloride uptake in amygdala kindled rats</title><author>Tietz, Elizabeth I. ; Chiu, Ted H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-eecec1bdfc5702982421f8d43ea791f3c729972c40c05047af1d1364934915073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amygdala - physiology</topic><topic>Animals</topic><topic>Benzodiazepine</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brainstem</topic><topic>Cerebellum</topic><topic>Cerebral cortex</topic><topic>Chloride flux</topic><topic>Chlorides - pharmacokinetics</topic><topic>Chlorine</topic><topic>Drug Synergism</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>Hippocampus</topic><topic>Kindling</topic><topic>Kindling, Neurologic</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Midazolam - pharmacology</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Radioisotopes</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Tissue Distribution</topic><topic>γ-Aminobutyric acid (GABA)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tietz, Elizabeth I.</creatorcontrib><creatorcontrib>Chiu, Ted H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tietz, Elizabeth I.</au><au>Chiu, Ted H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional GABA-stimulated chloride uptake in amygdala kindled rats</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1991-02-25</date><risdate>1991</risdate><volume>123</volume><issue>2</issue><spage>269</spage><epage>272</epage><pages>269-272</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>γ-Aminobutyric acid (GABA)-stimulated
36chloride (Cl
−) influx into membrane vesicles derived from cerebral cortex, hippocampus, cerebellum and midbrain/brainstem was evaluated in naive rats and amygdala or sham kindled rats. GABA-stimulated
36Cl
− uptake was greatest in cortex and hippocampus of naive rats. One week after amygdala kindling, 10 μM GABA-stimulated
36Cl
− influx was significantly reduced in each brain region, except midbrain/brainstem, indicating a regional variation in impaired GABAergic function. Midazolam potentiation of GABA-mediated Cl
− flux showed a regional variation. The effect of midazolam in kindled rats indicated either an increase in efficiency of GABA/benzodiazepine coupling in areas of reduced GABA function or its ability to restore Cl
− channel function to the pre-kindled state.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>2027542</pmid><doi>10.1016/0304-3940(91)90948-S</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1991-02, Vol.123 (2), p.269-272 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15893196 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amygdala - physiology Animals Benzodiazepine Biological and medical sciences Brain - metabolism Brainstem Cerebellum Cerebral cortex Chloride flux Chlorides - pharmacokinetics Chlorine Drug Synergism gamma-Aminobutyric Acid - pharmacology Hippocampus Kindling Kindling, Neurologic Male Medical sciences Midazolam - pharmacology Nervous system involvement in other diseases. Miscellaneous Neurology Radioisotopes Rats Rats, Inbred Strains Tissue Distribution γ-Aminobutyric acid (GABA) |
| title | Regional GABA-stimulated chloride uptake in amygdala kindled rats |
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