Involvement of MDR1 P‐glycoprotein in multifactorial resistance to methotrexate

Cellular resistance to methotrexate (MTX) is believed to be unaffected by expression of MDRI P‐glycoprotein (Pgp), a pleiotropic efflux pump acting on different hydrophobic compounds that enter cells by passive diffusion. A series of human leukemic CCRF‐CEM sublines, isolated by multi‐step selection...

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Veröffentlicht in:	International journal of cancer 1996-03, Vol.65 (5), p.613-619
Hauptverfasser:	Norris, Murray D., Graaf, David De, Haber, Michelle, Kavallaris, Maria, Madafiglio, Janice, Gilbert, Jayne, Kwan, Edward, Stewart, Bernard W., Mechetner, Eugene B., Gudkov, Andrei V., Roninson, Igor B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - metabolism Antimetabolites, Antineoplastic - toxicity Antineoplastic agents ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Biological and medical sciences Biological Transport Cell Division Chemotherapy Chick Embryo Drug Resistance, Multiple Flow Cytometry Gene Expression Regulation, Neoplastic Humans Medical sciences Methotrexate - metabolism Methotrexate - toxicity Pharmacology. Drug treatments RNA, Messenger - genetics Tumor Cells, Cultured
Online-Zugang:	Volltext
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