An immunotoxicity screening study on salmeterol in rats

Salmeterol, a long-acting β 2-adrenoreceptor agonist without known immunotoxicity, was studied in a 28-day repeated dose toxicity test in Wistar rats. Several immunotoxicity screening parameters were incorporated in the study protocol to investigate the immunotoxic potential of the compound. Male ra...

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Veröffentlicht in:	International journal of immunopharmacology 1996-08, Vol.18 (8), p.523-528
Hauptverfasser:	De Waal, Eric J., De Jong, Wim H., Van Der Vliet, Helen, Verlaan, Bert, Van Loveren, Henk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - toxicity Albuterol - analogs & derivatives Albuterol - toxicity Animals Anti-Inflammatory Agents, Non-Steroidal - toxicity Biological and medical sciences Bone Marrow - drug effects Bone Marrow - immunology Bone Marrow - pathology Drug Administration Schedule Drug Evaluation, Preclinical Drug toxicity and drugs side effects treatment Immunoglobulins - blood immunotoxicity screening Lymphocyte Subsets - drug effects Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Organ Size - drug effects Organ Size - immunology Organ Specificity - drug effects Organ Specificity - immunology Pharmacology. Drug treatments Platelet Count - drug effects Rats Rats, Wistar salmeterol Salmeterol Xinafoate Spleen - cytology
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