Complexity and diversity of mammalian adenylyl cyclases

Molecular cloning has permitted identification of several novel isoforms of mammalian adenylyl cyclase; these proteins now comprise a family of at least 10. All of the membrane-bound enzymes are activated by the alpha subunit of G alpha, a receptor-regulated, heterotrimeric guanine nucleotide-bindin...

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Veröffentlicht in:	Annual review of pharmacology and toxicology 1996-01, Vol.36 (1), p.461-480
Hauptverfasser:	Sunahara, R K, Dessauer, C W, Gilman, A G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - chemistry Adenylyl Cyclases - genetics Adenylyl Cyclases - isolation & purification Adenylyl Cyclases - metabolism Amino Acid Sequence Animals Calcium - metabolism Cloning, Molecular Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Drug Synergism GTP-Binding Proteins - metabolism Humans Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - isolation & purification Isoenzymes - metabolism Mammalia Molecular Sequence Data Phosphorylation Protein Kinase C - genetics Protein Kinase C - metabolism Tissue Distribution
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