Oxidative stress in neurodegenerative diseases
Oxidative stress refers to the cytopathologic consequences of a mismatch between the production of free radicals and the ability of the cell to defend against them. Growing data from experimental models and human brain studies suggest oxidative stress may play an important role in neuronal degenerat...
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| Veröffentlicht in: | Annual review of pharmacology and toxicology 1996, Vol.36, p.83-106 |
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| container_title | Annual review of pharmacology and toxicology |
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| creator | Simonian, N A Coyle, J T |
| description | Oxidative stress refers to the cytopathologic consequences of a mismatch between the production of free radicals and the ability of the cell to defend against them. Growing data from experimental models and human brain studies suggest oxidative stress may play an important role in neuronal degeneration in diseases such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. Mitochondrial oxidative metabolism, nitric oxide, phospholipid metabolism, and proteolytic pathways are potential sources of intracellular free radicals. Alterations in free radical defense systems may also contribute to oxidative stress. A net increase in reactive oxygen species can produce damage to lipids, proteins, and DNA and induce necrosis or apoptosis. Elucidating the pathways important in the production of and defense from free radicals may be important in devising new pharmacologic strategies to slow or halt neuronal degeneration. |
| doi_str_mv | 10.1146/annurev.pa.36.040196.000503 |
| format | Article |
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Growing data from experimental models and human brain studies suggest oxidative stress may play an important role in neuronal degeneration in diseases such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. Mitochondrial oxidative metabolism, nitric oxide, phospholipid metabolism, and proteolytic pathways are potential sources of intracellular free radicals. Alterations in free radical defense systems may also contribute to oxidative stress. A net increase in reactive oxygen species can produce damage to lipids, proteins, and DNA and induce necrosis or apoptosis. Elucidating the pathways important in the production of and defense from free radicals may be important in devising new pharmacologic strategies to slow or halt neuronal degeneration.</description><identifier>ISSN: 0362-1642</identifier><identifier>ISBN: 0824304365</identifier><identifier>ISBN: 9780824304362</identifier><identifier>EISSN: 1545-4304</identifier><identifier>DOI: 10.1146/annurev.pa.36.040196.000503</identifier><identifier>PMID: 8725383</identifier><language>eng</language><publisher>United States: Annual Reviews, Inc</publisher><subject>Alzheimer Disease - physiopathology ; Amyotrophic Lateral Sclerosis - physiopathology ; Apoptosis - physiology ; Arachidonic Acid - metabolism ; Electron Transport ; Endopeptidases - metabolism ; Enzyme Activation ; Free Radicals - adverse effects ; Free Radicals - metabolism ; Humans ; Mitochondria - metabolism ; Necrosis - physiopathology ; Nerve Degeneration - physiology ; Nitric Oxide - metabolism ; Oxidation-Reduction ; Oxidative Stress ; Parkinson Disease - physiopathology</subject><ispartof>Annual review of pharmacology and toxicology, 1996, Vol.36, p.83-106</ispartof><rights>Copyright Annual Reviews, Inc. 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8725383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simonian, N A</creatorcontrib><creatorcontrib>Coyle, J T</creatorcontrib><title>Oxidative stress in neurodegenerative diseases</title><title>Annual review of pharmacology and toxicology</title><addtitle>Annu Rev Pharmacol Toxicol</addtitle><description>Oxidative stress refers to the cytopathologic consequences of a mismatch between the production of free radicals and the ability of the cell to defend against them. 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Elucidating the pathways important in the production of and defense from free radicals may be important in devising new pharmacologic strategies to slow or halt neuronal degeneration.</description><subject>Alzheimer Disease - physiopathology</subject><subject>Amyotrophic Lateral Sclerosis - physiopathology</subject><subject>Apoptosis - physiology</subject><subject>Arachidonic Acid - metabolism</subject><subject>Electron Transport</subject><subject>Endopeptidases - metabolism</subject><subject>Enzyme Activation</subject><subject>Free Radicals - adverse effects</subject><subject>Free Radicals - metabolism</subject><subject>Humans</subject><subject>Mitochondria - metabolism</subject><subject>Necrosis - physiopathology</subject><subject>Nerve Degeneration - physiology</subject><subject>Nitric Oxide - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Parkinson Disease - physiopathology</subject><issn>0362-1642</issn><issn>1545-4304</issn><isbn>0824304365</isbn><isbn>9780824304362</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkNtKw0AQhhcP1Lb6CEJR8C5xz4dLKZ6g0Bu9DrvZiaS0m7ibFH37rrRXzjD8A_P9wzAI3RNcEsLlow1hjLAve1syWWKOicmCscDsDE2J4KLgDPNzNMOa_nVMigs0xUzSgkhOr9AspU02GMbJBE20ooJpNkXl-qf1dmj3sEhDhJQWbVgEGGPn4QsCxOPMtwlsgnSNLhu7TXBz0jn6fHn-WL4Vq_Xr-_JpVfRU8qHwJqdz1BuOG03BeMaYqRtDHcmlsBIMEydq4wylGoDTWinlGux9Y2rD5ujhuLeP3fcIaah2baphu7UBujFVRGglc2Tw7h-46cYY8m0VxUILwTXJ0O0JGt0OfNXHdmfjb3X6AjsAnpVjxw</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>Simonian, N A</creator><creator>Coyle, J T</creator><general>Annual Reviews, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7TK</scope></search><sort><creationdate>1996</creationdate><title>Oxidative stress in neurodegenerative diseases</title><author>Simonian, N A ; Coyle, J T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p264t-d9d9dbb2d940f82e9d3339cf92b192b7075301b5c9b9228ee42c777bf0ddf9c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Alzheimer Disease - physiopathology</topic><topic>Amyotrophic Lateral Sclerosis - physiopathology</topic><topic>Apoptosis - physiology</topic><topic>Arachidonic Acid - metabolism</topic><topic>Electron Transport</topic><topic>Endopeptidases - metabolism</topic><topic>Enzyme Activation</topic><topic>Free Radicals - adverse effects</topic><topic>Free Radicals - metabolism</topic><topic>Humans</topic><topic>Mitochondria - metabolism</topic><topic>Necrosis - physiopathology</topic><topic>Nerve Degeneration - physiology</topic><topic>Nitric Oxide - metabolism</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress</topic><topic>Parkinson Disease - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simonian, N A</creatorcontrib><creatorcontrib>Coyle, J T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Neurosciences Abstracts</collection><jtitle>Annual review of pharmacology and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simonian, N A</au><au>Coyle, J T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative stress in neurodegenerative diseases</atitle><jtitle>Annual review of pharmacology and toxicology</jtitle><addtitle>Annu Rev Pharmacol Toxicol</addtitle><date>1996</date><risdate>1996</risdate><volume>36</volume><spage>83</spage><epage>106</epage><pages>83-106</pages><issn>0362-1642</issn><eissn>1545-4304</eissn><isbn>0824304365</isbn><isbn>9780824304362</isbn><abstract>Oxidative stress refers to the cytopathologic consequences of a mismatch between the production of free radicals and the ability of the cell to defend against them. 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| identifier | ISSN: 0362-1642 |
| ispartof | Annual review of pharmacology and toxicology, 1996, Vol.36, p.83-106 |
| issn | 0362-1642 1545-4304 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15876666 |
| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Alzheimer Disease - physiopathology Amyotrophic Lateral Sclerosis - physiopathology Apoptosis - physiology Arachidonic Acid - metabolism Electron Transport Endopeptidases - metabolism Enzyme Activation Free Radicals - adverse effects Free Radicals - metabolism Humans Mitochondria - metabolism Necrosis - physiopathology Nerve Degeneration - physiology Nitric Oxide - metabolism Oxidation-Reduction Oxidative Stress Parkinson Disease - physiopathology |
| title | Oxidative stress in neurodegenerative diseases |
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