Clastogenicity of Eucommiae Cortex and Astragali Radix

In order to further investigate the genotoxic effects of Sophorae Flos, Astragali Radix and Eucommiae Cortex which are reported to induce mutagenicity in Ames test, a chromosome aberration study of the water extracts of these crude drugs was carried out using cultured Chinese hamster lung cells. Sop...

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Veröffentlicht in:	Eisei kagaku 1995/12/31, Vol.41(6), pp.463-469
Hauptverfasser:	TADAKI, SHINICHI, YAMADA, SAYURI, MIYAZAWA, NORIMASA, NOZAKA, TOMIO, TANAKA, AKIO
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	Ames test Astragali Radix clastogenicity Eucommiae Cortex mutagenicity Sophorae Flos
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creator	TADAKI, SHINICHI YAMADA, SAYURI MIYAZAWA, NORIMASA NOZAKA, TOMIO TANAKA, AKIO
description	In order to further investigate the genotoxic effects of Sophorae Flos, Astragali Radix and Eucommiae Cortex which are reported to induce mutagenicity in Ames test, a chromosome aberration study of the water extracts of these crude drugs was carried out using cultured Chinese hamster lung cells. Sophorae Flos did not induce chromosomal aberrations in either direct method or S9 Mix method. In the S9 Mix method, Astragali Radix at a dose of 1.25 mg/ml modestly increased the incidence of aberrant cells (16%). Eucommiae Cortex was strongly clastogenic to the cells and dramatically elevated the incidence of aberrant cells (98%) at a concentration of 4.55 mg/ml in the direct method. These results suggest that Astragali Radix and Eucommiae Cortex may be genotoxic to mammalian cells
doi_str_mv	10.1248/jhs1956.41.463
format	Article
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Sophorae Flos did not induce chromosomal aberrations in either direct method or S9 Mix method. In the S9 Mix method, Astragali Radix at a dose of 1.25 mg/ml modestly increased the incidence of aberrant cells (16%). Eucommiae Cortex was strongly clastogenic to the cells and dramatically elevated the incidence of aberrant cells (98%) at a concentration of 4.55 mg/ml in the direct method. 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source	J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals
subjects	Ames test Astragali Radix clastogenicity Eucommiae Cortex mutagenicity Sophorae Flos
title	Clastogenicity of Eucommiae Cortex and Astragali Radix
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