N -Methyl- D -aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss

The use of aminoglycoside antibiotics is limited by ototoxicity that can produce permanent hearing loss. We report that concurrent administration of N –methyl– D –aspartate (NMDA) antagonists markedly attenuates both the hearing loss and destruction of cochlear hair cells in guinea pigs treated with...

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Veröffentlicht in:	Nature medicine 1996-12, Vol.2 (12), p.1338-1343
Hauptverfasser:	Basile, Anthony S, Huang, Jer-Min, Xie, Chen, Webster, Douglas, Berlin, Charles, Skolnick, Phil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - adverse effects Biomedical and Life Sciences Biomedicine Cancer Research Cochlea - pathology Dizocilpine Maleate - metabolism Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - metabolism Excitatory Amino Acid Antagonists - pharmacology Guinea Pigs Hair Cells, Auditory Hearing Loss - chemically induced Hearing Loss - pathology Hearing Loss - prevention & control Hearing Tests Infectious Diseases Kanamycin - adverse effects Male Metabolic Diseases Molecular Medicine N-Methylaspartate - antagonists & inhibitors Neomycin - adverse effects Neurosciences Piperidines - metabolism Piperidines - pharmacology Prosencephalon Radioligand Assay Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism
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