An ACTH-(4–9) analogue, Org 2766, improves recovery from acrylamide neuropathy in rats

Org 2766 is one of a series of melanocortis (ACTH and related peptides) that exert trophic influences on the central and peripheral nervous system of the rat. We used acrylamide neuropathy in rats as an experimental model of peripheral neuropathies of the dying-back type in order to assess the poten...

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Veröffentlicht in:	European journal of pharmacology 1990-09, Vol.186 (2), p.181-187
Hauptverfasser:	Sporel-Özakat, R.Emine, Edwards, Philippa M., Van der Hoop, Roland Gerritsen, Gispen, Willem H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide Acrylamides Adrenocorticotropic Hormone - analogs & derivatives Adrenocorticotropic Hormone - therapeutic use Animals Anticonvulsants - therapeutic use Biological and medical sciences Electrophysiology Female Medical sciences Melanocortins Miscellaneous Motor Neurons - drug effects Motor Neurons - metabolism Nervous System Diseases - chemically induced Nervous System Diseases - drug therapy Neuropathy (peripheral) Neuropharmacology Peptide Fragments - therapeutic use Pharmacology. Drug treatments Postural Balance - drug effects Psychomotor Performance - drug effects Rats Rats, Inbred Strains Synaptic Transmission - drug effects
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