Humoral and Cellular Immune Responses following Vaccination with Purified Recombinant Hemagglutinin from Influenza A (H3N2) Virus

Adults were immunized with either baculovirus-expressed, purified recombinant hemagglutinin (rHA) from influenza A/Beijing/32/92 (H3N2) virus or saline placebo and evaluated for humoral and in vitro cellular immune responses. Compared with responses in placebo recipients, vaccinees had greater postv...

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Veröffentlicht in:	The Journal of infectious diseases 1997-02, Vol.175 (2), p.342-351
Hauptverfasser:	Powers, Douglas C., McElhaney, Janet E., Florendo, Oscar A., Manning, Mary C., Upshaw, Craig M., Bentley, David W., Wilkinson, Bethanie E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibodies Antibodies, Viral - immunology Antigens B-Lymphocytes - immunology Biological and medical sciences Cell Division - immunology Cytokines Cytotoxicity Tests, Immunologic H3N2 subtype influenza A virus Hemagglutination Inhibition Tests Hemagglutinins, Viral - genetics Hemagglutinins, Viral - immunology Human viral diseases Humans Immunity, Cellular Immunization Immunologic Memory Infections Infectious diseases Influenza A virus Influenza A virus - genetics Influenza A virus - immunology Influenza A Virus, H3N2 Subtype Influenza vaccines Influenza, Human - blood Influenza, Human - immunology Influenza, Human - prevention & control Interferon-gamma - metabolism Interleukin-10 - metabolism Interleukin-2 - metabolism Interleukin-4 - metabolism Lymphocytes - cytology Lymphocytes - immunology Lymphocytes - metabolism Major Articles Medical sciences Middle Aged Placebos Recombinant Proteins - immunology T lymphocytes T-Lymphocytes, Cytotoxic - immunology Vaccination Vaccines, Synthetic - immunology Viral diseases Viral diseases of the respiratory system and ent viral diseases
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