$Schedule-dependent therapeutic gain from the combination of fractionated irradiation plus c-DDP and 5-FU or plus c-DDP and cyclophosphamide in C3H/Km mouse model systems$

Schedule-dependent therapeutic gain from the combination of fractionated irradiation plus c-DDP and 5-FU or plus c-DDP and cyclophosphamide in C3H/Km mouse model systems

Cytotoxic drugs were administered either in single or fractionated doses before, during, or after a standard course of 5 daily X ray exposures. SCCVII and RIF-1 tumors were grown from cells implanted in the gastrocnemius muscles of syngeneic C3H/Km mice, and treatments were evaluated by regrowth del...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 1991-02, Vol.20 (2), p.227-232
Hauptverfasser:	Kallman, R F, Rapacchietta, D, Zaghloul, M S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cisplatin - administration & dosage Combined Modality Therapy Cyclophosphamide - administration & dosage Drug Administration Schedule Fluorouracil - administration & dosage Male Mice Mice, Inbred C3H Neoplasms, Experimental - therapy Radiation Tolerance - drug effects
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