Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw
The nitric oxide synthase (NOS) inhibitor t,-nitroarginine methyl ester has been found to exhibit antinociceptive activity in a rat model of pain [Kitto, K.F. et al., Neurosci. Lett., 148 (1992) 1–5; Lee, J.H. et al., NeuroReport, 3 (]992) 841–844; Moore, P.K. et al., Br. J. Pharmacol., 102 (1991) 1...
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| Veröffentlicht in: | Neuroscience letters 1996-06, Vol.210 (3), p.201-204 |
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| creator | Lam, H.H.D. Hanley, D.F. Trapp, B.D. Saito, S. Raja, S. Dawson, T.M. Yamaguchi, H. |
| description | The nitric oxide synthase (NOS) inhibitor t,-nitroarginine methyl ester has been found to exhibit antinociceptive activity in a rat model of pain [Kitto, K.F. et al., Neurosci. Lett., 148 (1992) 1–5; Lee, J.H. et al., NeuroReport, 3 (]992) 841–844; Moore, P.K. et al., Br. J. Pharmacol., 102 (1991) 198–202]. We investigated the hypothesis that hind paw injection of formalin increases the number of dorsal horn neuronal nitric oxide synthase (nNOS) containing neurons. Results showed a bilateral increase in the number of nNOS-positive neurons at the L4–5 dorsal horn area following formalin injection. The increase was always greater on the ipsilateral side compared to the contralateral side. This upregulation of nNOS following formalin stimulation of the hind paw suggested that nitric oxide (NO) may play a role in the central mechanism of hyperalgesia that follows peripheral inflammation. |
| doi_str_mv | 10.1016/0304-3940(96)12702-6 |
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Lett., 148 (1992) 1–5; Lee, J.H. et al., NeuroReport, 3 (]992) 841–844; Moore, P.K. et al., Br. J. Pharmacol., 102 (1991) 198–202]. We investigated the hypothesis that hind paw injection of formalin increases the number of dorsal horn neuronal nitric oxide synthase (nNOS) containing neurons. Results showed a bilateral increase in the number of nNOS-positive neurons at the L4–5 dorsal horn area following formalin injection. The increase was always greater on the ipsilateral side compared to the contralateral side. This upregulation of nNOS following formalin stimulation of the hind paw suggested that nitric oxide (NO) may play a role in the central mechanism of hyperalgesia that follows peripheral inflammation.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(96)12702-6</identifier><identifier>PMID: 8805130</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Enzyme Induction - drug effects ; Enzyme Induction - physiology ; Foot - physiology ; Formaldehyde - administration & dosage ; Fundamental and applied biological sciences. Psychology ; Induction ; Injections ; Injury ; Male ; NG-Nitroarginine Methyl Ester - pharmacology ; Nitric oxide synthase ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitric Oxide Synthase - biosynthesis ; Pain ; Pain - chemically induced ; Pain - enzymology ; Rats ; Rats, Sprague-Dawley ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Spinal cord ; Spinal Cord - cytology ; Spinal Cord - physiology ; Up-Regulation - drug effects ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1996-06, Vol.210 (3), p.201-204</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-d9583975b3c6db51673c97f718874e8145a50919121fbeddecb223f7cfc471e3</citedby><cites>FETCH-LOGICAL-c483t-d9583975b3c6db51673c97f718874e8145a50919121fbeddecb223f7cfc471e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(96)12702-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3138430$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8805130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lam, H.H.D.</creatorcontrib><creatorcontrib>Hanley, D.F.</creatorcontrib><creatorcontrib>Trapp, B.D.</creatorcontrib><creatorcontrib>Saito, S.</creatorcontrib><creatorcontrib>Raja, S.</creatorcontrib><creatorcontrib>Dawson, T.M.</creatorcontrib><creatorcontrib>Yamaguchi, H.</creatorcontrib><title>Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The nitric oxide synthase (NOS) inhibitor t,-nitroarginine methyl ester has been found to exhibit antinociceptive activity in a rat model of pain [Kitto, K.F. et al., Neurosci. Lett., 148 (1992) 1–5; Lee, J.H. et al., NeuroReport, 3 (]992) 841–844; Moore, P.K. et al., Br. J. Pharmacol., 102 (1991) 198–202]. We investigated the hypothesis that hind paw injection of formalin increases the number of dorsal horn neuronal nitric oxide synthase (nNOS) containing neurons. Results showed a bilateral increase in the number of nNOS-positive neurons at the L4–5 dorsal horn area following formalin injection. The increase was always greater on the ipsilateral side compared to the contralateral side. This upregulation of nNOS following formalin stimulation of the hind paw suggested that nitric oxide (NO) may play a role in the central mechanism of hyperalgesia that follows peripheral inflammation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Enzyme Induction - drug effects</subject><subject>Enzyme Induction - physiology</subject><subject>Foot - physiology</subject><subject>Formaldehyde - administration & dosage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Induction</subject><subject>Injections</subject><subject>Injury</subject><subject>Male</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Nitric oxide synthase</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase - biosynthesis</subject><subject>Pain</subject><subject>Pain - chemically induced</subject><subject>Pain - enzymology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Spinal cord</subject><subject>Spinal Cord - cytology</subject><subject>Spinal Cord - physiology</subject><subject>Up-Regulation - drug effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpSbdp_0ELOpSQHNxqLNmSLoUS-hEIzaG5C1kasVq80lay0-bfx5td9tjTzDDPvAwPIe-BfQIG_WfGmWi4FuxS91fQStY2_QuyAiXbRmrZviSrE_KavKl1wxjroBNn5EyppeNsRTY3yc9uijnRHGjdxWRH6nLxNOFc8n5KcSrR0fwveqT1MU1rW5Fe_rr7fUVtmLDQkMvWjjHRmDZ4CFuGaY202ImuY_J0Z_--Ja-CHSu-O9Zzcv_92_31z-b27sfN9dfbxgnFp8brTnEtu4G73g8d9JI7LYMEpaRABaKzHdOgoYUwoPfohrblQbrghATk5-TiELsr-c-MdTLbWB2Oo02Y52qgUz0o3S6gOICu5FoLBrMrcWvLowFm9obNXp_Z6zO6N8-GTb-cfTjmz8MW_enoqHTZfzzubXV2DMUmF-sJ48CVeMa-HDBcVDxELKa6iMmhj2VxaHyO___jCdgqlvE</recordid><startdate>19960607</startdate><enddate>19960607</enddate><creator>Lam, H.H.D.</creator><creator>Hanley, D.F.</creator><creator>Trapp, B.D.</creator><creator>Saito, S.</creator><creator>Raja, S.</creator><creator>Dawson, T.M.</creator><creator>Yamaguchi, H.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19960607</creationdate><title>Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw</title><author>Lam, H.H.D. ; Hanley, D.F. ; Trapp, B.D. ; Saito, S. ; Raja, S. ; Dawson, T.M. ; Yamaguchi, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-d9583975b3c6db51673c97f718874e8145a50919121fbeddecb223f7cfc471e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Enzyme Induction - drug effects</topic><topic>Enzyme Induction - physiology</topic><topic>Foot - physiology</topic><topic>Formaldehyde - administration & dosage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Induction</topic><topic>Injections</topic><topic>Injury</topic><topic>Male</topic><topic>NG-Nitroarginine Methyl Ester - pharmacology</topic><topic>Nitric oxide synthase</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase - biosynthesis</topic><topic>Pain</topic><topic>Pain - chemically induced</topic><topic>Pain - enzymology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Spinal cord</topic><topic>Spinal Cord - cytology</topic><topic>Spinal Cord - physiology</topic><topic>Up-Regulation - drug effects</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lam, H.H.D.</creatorcontrib><creatorcontrib>Hanley, D.F.</creatorcontrib><creatorcontrib>Trapp, B.D.</creatorcontrib><creatorcontrib>Saito, S.</creatorcontrib><creatorcontrib>Raja, S.</creatorcontrib><creatorcontrib>Dawson, T.M.</creatorcontrib><creatorcontrib>Yamaguchi, H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lam, H.H.D.</au><au>Hanley, D.F.</au><au>Trapp, B.D.</au><au>Saito, S.</au><au>Raja, S.</au><au>Dawson, T.M.</au><au>Yamaguchi, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1996-06-07</date><risdate>1996</risdate><volume>210</volume><issue>3</issue><spage>201</spage><epage>204</epage><pages>201-204</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The nitric oxide synthase (NOS) inhibitor t,-nitroarginine methyl ester has been found to exhibit antinociceptive activity in a rat model of pain [Kitto, K.F. et al., Neurosci. Lett., 148 (1992) 1–5; Lee, J.H. et al., NeuroReport, 3 (]992) 841–844; Moore, P.K. et al., Br. J. Pharmacol., 102 (1991) 198–202]. We investigated the hypothesis that hind paw injection of formalin increases the number of dorsal horn neuronal nitric oxide synthase (nNOS) containing neurons. Results showed a bilateral increase in the number of nNOS-positive neurons at the L4–5 dorsal horn area following formalin injection. The increase was always greater on the ipsilateral side compared to the contralateral side. This upregulation of nNOS following formalin stimulation of the hind paw suggested that nitric oxide (NO) may play a role in the central mechanism of hyperalgesia that follows peripheral inflammation.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8805130</pmid><doi>10.1016/0304-3940(96)12702-6</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1996-06, Vol.210 (3), p.201-204 |
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| subjects | Animals Biological and medical sciences Enzyme Induction - drug effects Enzyme Induction - physiology Foot - physiology Formaldehyde - administration & dosage Fundamental and applied biological sciences. Psychology Induction Injections Injury Male NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide synthase Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - biosynthesis Pain Pain - chemically induced Pain - enzymology Rats Rats, Sprague-Dawley Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal cord Spinal Cord - cytology Spinal Cord - physiology Up-Regulation - drug effects Vertebrates: nervous system and sense organs |
| title | Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw |
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