F-Fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot study
Primary hyperparathyroidism is a common endocrine disorder which is diagnosed biochemically and for which therapy is surgical. A prerequisite for minimally invasive surgery, which minimizes morbidity and cost, is accurate localization of the involved gland(s). The aim of this study was to evaluate t...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2014-11, Vol.41 (11), p.2083-2089 |
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| container_title | European journal of nuclear medicine and molecular imaging |
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| creator | Lezaic, Luka Rep, Sebastijan Sever, Mojca Jensterle Kocjan, Tomaz Hocevar, Marko Fettich, Jure |
| description | Primary hyperparathyroidism is a common endocrine disorder which is diagnosed biochemically and for which therapy is surgical. A prerequisite for minimally invasive surgery, which minimizes morbidity and cost, is accurate localization of the involved gland(s). The aim of this study was to evaluate the usefulness of (18)F-fluorocholine PET/CT for preoperative localization of hyperfunctioning parathyroid tissue.
(18)F-Fluorocholine PET/CT and conventional parathyroid scintigraphic imaging consisting of (99m)Tc-sestaMIBI SPECT/CT, (99m)Tc-sestaMIBI dual-phase imaging and (99m)Tc-sestaMIBI/pertechnetate subtraction imaging were performed in 24 patients. The diagnostic performance of the imaging methods was compared against histology as the gold standard and postoperative serum Ca(2+) and iPTH values.
The sensitivity and specificity of (18)F-fluorocholine PET/CT were 92% and 100%, respectively, in contrast to 49% and 100%, 46% and 100%, and 44% and 100% for (99m)Tc-sestaMIBI SPECT/CT, (99m)Tc-sestaMIBI/pertechnetate subtraction imaging and (99m)Tc-sestaMIBI dual-phase imaging, respectively. Combined conventional scintigraphic imaging had a sensitivity and specificity of 64% and 100%, respectively. The performance of (18)F-fluorocholine PET/CT was superior particularly in patients with multiple lesions or hyperplasia.
(18)F-Fluorocholine PET/CT appears to be a promising, effective imaging method for localization of hyperfunctioning parathyroid tissue. |
| doi_str_mv | 10.1007/s00259-014-2837-0 |
| format | Article |
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(18)F-Fluorocholine PET/CT and conventional parathyroid scintigraphic imaging consisting of (99m)Tc-sestaMIBI SPECT/CT, (99m)Tc-sestaMIBI dual-phase imaging and (99m)Tc-sestaMIBI/pertechnetate subtraction imaging were performed in 24 patients. The diagnostic performance of the imaging methods was compared against histology as the gold standard and postoperative serum Ca(2+) and iPTH values.
The sensitivity and specificity of (18)F-fluorocholine PET/CT were 92% and 100%, respectively, in contrast to 49% and 100%, 46% and 100%, and 44% and 100% for (99m)Tc-sestaMIBI SPECT/CT, (99m)Tc-sestaMIBI/pertechnetate subtraction imaging and (99m)Tc-sestaMIBI dual-phase imaging, respectively. Combined conventional scintigraphic imaging had a sensitivity and specificity of 64% and 100%, respectively. The performance of (18)F-fluorocholine PET/CT was superior particularly in patients with multiple lesions or hyperplasia.
(18)F-Fluorocholine PET/CT appears to be a promising, effective imaging method for localization of hyperfunctioning parathyroid tissue.</description><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-014-2837-0</identifier><identifier>PMID: 25063039</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Aged ; Choline - analogs & derivatives ; Female ; Follow-Up Studies ; Humans ; Hyperparathyroidism, Primary - diagnostic imaging ; Hyperparathyroidism, Primary - pathology ; Hyperparathyroidism, Primary - surgery ; Hyperplasia - diagnostic imaging ; Male ; Middle Aged ; Multimodal Imaging ; Parathyroid Glands - diagnostic imaging ; Parathyroid Glands - pathology ; Parathyroid Glands - surgery ; Parathyroid Neoplasms - diagnostic imaging ; Pilot Projects ; Positron-Emission Tomography ; Tomography, X-Ray Computed</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2014-11, Vol.41 (11), p.2083-2089</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25063039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lezaic, Luka</creatorcontrib><creatorcontrib>Rep, Sebastijan</creatorcontrib><creatorcontrib>Sever, Mojca Jensterle</creatorcontrib><creatorcontrib>Kocjan, Tomaz</creatorcontrib><creatorcontrib>Hocevar, Marko</creatorcontrib><creatorcontrib>Fettich, Jure</creatorcontrib><title>F-Fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot study</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Primary hyperparathyroidism is a common endocrine disorder which is diagnosed biochemically and for which therapy is surgical. A prerequisite for minimally invasive surgery, which minimizes morbidity and cost, is accurate localization of the involved gland(s). The aim of this study was to evaluate the usefulness of (18)F-fluorocholine PET/CT for preoperative localization of hyperfunctioning parathyroid tissue.
(18)F-Fluorocholine PET/CT and conventional parathyroid scintigraphic imaging consisting of (99m)Tc-sestaMIBI SPECT/CT, (99m)Tc-sestaMIBI dual-phase imaging and (99m)Tc-sestaMIBI/pertechnetate subtraction imaging were performed in 24 patients. The diagnostic performance of the imaging methods was compared against histology as the gold standard and postoperative serum Ca(2+) and iPTH values.
The sensitivity and specificity of (18)F-fluorocholine PET/CT were 92% and 100%, respectively, in contrast to 49% and 100%, 46% and 100%, and 44% and 100% for (99m)Tc-sestaMIBI SPECT/CT, (99m)Tc-sestaMIBI/pertechnetate subtraction imaging and (99m)Tc-sestaMIBI dual-phase imaging, respectively. Combined conventional scintigraphic imaging had a sensitivity and specificity of 64% and 100%, respectively. The performance of (18)F-fluorocholine PET/CT was superior particularly in patients with multiple lesions or hyperplasia.
(18)F-Fluorocholine PET/CT appears to be a promising, effective imaging method for localization of hyperfunctioning parathyroid tissue.</description><subject>Adult</subject><subject>Aged</subject><subject>Choline - analogs & derivatives</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hyperparathyroidism, Primary - diagnostic imaging</subject><subject>Hyperparathyroidism, Primary - pathology</subject><subject>Hyperparathyroidism, Primary - surgery</subject><subject>Hyperplasia - diagnostic imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multimodal Imaging</subject><subject>Parathyroid Glands - diagnostic imaging</subject><subject>Parathyroid Glands - pathology</subject><subject>Parathyroid Glands - surgery</subject><subject>Parathyroid Neoplasms - diagnostic imaging</subject><subject>Pilot Projects</subject><subject>Positron-Emission Tomography</subject><subject>Tomography, X-Ray Computed</subject><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEFLxDAQhYMg7rr6A7xIjl7iTpo2TbzJ4qqwoIf1XLJp4kbSpibtoeKPt7IreHkzb_gYeA-hKwq3FKBcJoCskARoTjLBSgInaE45laQEIWfoPKUPACoyIc_QLCuAM2Byjr7XZO2HEIPeB-9ag18ftsvVFtsQsQ9aefelehdaHCzej52Jdmj178G177hTUfX7MQZX496lNBjsWtxF16g4HvB_iEvNHVa4cz70OPVDPV6gU6t8MpfHuUBv64ft6olsXh6fV_cb0lHJe6K4Bp7tJrHApQHJVF5MCWo7mZypwrC8LIVgRW1NJpnmtWF6p_W0Z6wEtkA3h79dDJ-DSX3VuKSN96o1YUgVLQSnIHleTOj1ER12jamrY5jqrzH2A8EzbkA</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Lezaic, Luka</creator><creator>Rep, Sebastijan</creator><creator>Sever, Mojca Jensterle</creator><creator>Kocjan, Tomaz</creator><creator>Hocevar, Marko</creator><creator>Fettich, Jure</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20141101</creationdate><title>F-Fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot study</title><author>Lezaic, Luka ; Rep, Sebastijan ; Sever, Mojca Jensterle ; Kocjan, Tomaz ; Hocevar, Marko ; Fettich, Jure</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p196t-a6c062bc06f069e093a45506df9e043a5e34778835dfe293c6de3cbcc29323703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Choline - analogs & derivatives</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hyperparathyroidism, Primary - diagnostic imaging</topic><topic>Hyperparathyroidism, Primary - pathology</topic><topic>Hyperparathyroidism, Primary - surgery</topic><topic>Hyperplasia - diagnostic imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multimodal Imaging</topic><topic>Parathyroid Glands - diagnostic imaging</topic><topic>Parathyroid Glands - pathology</topic><topic>Parathyroid Glands - surgery</topic><topic>Parathyroid Neoplasms - diagnostic imaging</topic><topic>Pilot Projects</topic><topic>Positron-Emission Tomography</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lezaic, Luka</creatorcontrib><creatorcontrib>Rep, Sebastijan</creatorcontrib><creatorcontrib>Sever, Mojca Jensterle</creatorcontrib><creatorcontrib>Kocjan, Tomaz</creatorcontrib><creatorcontrib>Hocevar, Marko</creatorcontrib><creatorcontrib>Fettich, Jure</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lezaic, Luka</au><au>Rep, Sebastijan</au><au>Sever, Mojca Jensterle</au><au>Kocjan, Tomaz</au><au>Hocevar, Marko</au><au>Fettich, Jure</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>F-Fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot study</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>41</volume><issue>11</issue><spage>2083</spage><epage>2089</epage><pages>2083-2089</pages><eissn>1619-7089</eissn><abstract>Primary hyperparathyroidism is a common endocrine disorder which is diagnosed biochemically and for which therapy is surgical. A prerequisite for minimally invasive surgery, which minimizes morbidity and cost, is accurate localization of the involved gland(s). The aim of this study was to evaluate the usefulness of (18)F-fluorocholine PET/CT for preoperative localization of hyperfunctioning parathyroid tissue.
(18)F-Fluorocholine PET/CT and conventional parathyroid scintigraphic imaging consisting of (99m)Tc-sestaMIBI SPECT/CT, (99m)Tc-sestaMIBI dual-phase imaging and (99m)Tc-sestaMIBI/pertechnetate subtraction imaging were performed in 24 patients. The diagnostic performance of the imaging methods was compared against histology as the gold standard and postoperative serum Ca(2+) and iPTH values.
The sensitivity and specificity of (18)F-fluorocholine PET/CT were 92% and 100%, respectively, in contrast to 49% and 100%, 46% and 100%, and 44% and 100% for (99m)Tc-sestaMIBI SPECT/CT, (99m)Tc-sestaMIBI/pertechnetate subtraction imaging and (99m)Tc-sestaMIBI dual-phase imaging, respectively. Combined conventional scintigraphic imaging had a sensitivity and specificity of 64% and 100%, respectively. The performance of (18)F-fluorocholine PET/CT was superior particularly in patients with multiple lesions or hyperplasia.
(18)F-Fluorocholine PET/CT appears to be a promising, effective imaging method for localization of hyperfunctioning parathyroid tissue.</abstract><cop>Germany</cop><pmid>25063039</pmid><doi>10.1007/s00259-014-2837-0</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Choline - analogs & derivatives Female Follow-Up Studies Humans Hyperparathyroidism, Primary - diagnostic imaging Hyperparathyroidism, Primary - pathology Hyperparathyroidism, Primary - surgery Hyperplasia - diagnostic imaging Male Middle Aged Multimodal Imaging Parathyroid Glands - diagnostic imaging Parathyroid Glands - pathology Parathyroid Glands - surgery Parathyroid Neoplasms - diagnostic imaging Pilot Projects Positron-Emission Tomography Tomography, X-Ray Computed |
| title | F-Fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot study |
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