Design of anticoagulant surfaces based on cellulose nanocrystals
The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is d...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2014-11, Vol.50 (86), p.13070-13072 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 50 |
| creator | Ehmann, Heike M A Mohan, Tamilselvan Koshanskaya, Maria Scheicher, Sylvia Breitwieser, Doris Ribitsch, Volker Stana-Kleinschek, Karin Spirk, Stefan |
| description | The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is demonstrated that CNC decorated surfaces significantly enhance the coagulation times of blood plasma and whole blood as proven by QCM-D and simple clotting tests. |
| doi_str_mv | 10.1039/c4cc05254d |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2014-11, Vol.50 (86), p.13070-13072 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Anticoagulants - chemistry Anticoagulants - pharmacology Blood Coagulation - drug effects Cellulose - chemistry Heparin - chemistry Heparin - pharmacology Humans Hydrolysis Nanoparticles - chemistry Polyethyleneimine - chemistry Sulfuric Acids - chemistry Surface Properties |
| title | Design of anticoagulant surfaces based on cellulose nanocrystals |
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