KIR ligand C2 is associated with increased susceptibility to childhood ALL and confers an elevated risk for late relapse

A role for HLA class I polymorphism in childhood acute lymphoblastic leukemia (ALL) has been suggested for many years, but unambiguous associations have not been found. Here, we show that the HLA-C–encoded supertypic epitope C2, which constitutes a high-affinity ligand for the inhibitory natural kil...

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