Effectiveness of trivalent flu vaccine in healthy young children
There are few studies evaluating the effectiveness of trivalent influenza vaccination (TIV) in young children, particularly in children
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| Veröffentlicht in: | Pediatrics (Evanston) 2014-05, Vol.133 (5), p.e1218-e1225 |
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| container_title | Pediatrics (Evanston) |
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| creator | Blyth, Christopher C Jacoby, Peter Effler, Paul V Kelly, Heath Smith, David W Robins, Christine Willis, Gabriela A Levy, Avram Keil, Anthony D Richmond, Peter C |
| description | There are few studies evaluating the effectiveness of trivalent influenza vaccination (TIV) in young children, particularly in children |
| doi_str_mv | 10.1542/peds.2013-3707 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1586101245</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A368534368</galeid><sourcerecordid>A368534368</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-e8364e6059d5ee95d42b7d3d5f4083a3e7e6623963e32d46ec03005b85492c413</originalsourceid><addsrcrecordid>eNpdkT1PwzAQhi0EgvKxMqJILCwpZ5_tJBuo4kuqxAKzlTqXNsh1SpxU9N_jqMDAcrc8d3ruXsYuOUy5kuJ2Q1WYCuCYYgbZAZtwKPJUikwdsgkA8lQCqBN2GsIHAEiViWN2ImSmUAk1YXcPdU22b7bkKYSkrZO-a7alI98ntRuSbWlt4ylpfLKi0vWrXbJrB79M7KpxVUf-nB3VpQt08dPP2Pvjw9vsOZ2_Pr3M7uepRc37lHLUkjSoolJEhaqkWGQVVqqWkGOJlJHWAguNhKKSmixgFF_kShbCSo5n7Ga_d9O1nwOF3qybYMm50lM7BMNVrjlwIVVEr_-hH-3Q-WgXKSGF0pCNC9M9tYzXmsbb1vf01dvWOVqSifKzV3OPOlcoY438dM_brg2ho9psumZddjvDwYxZmDELM2ZhxiziwNWPxrBYU_WH_z4fvwFJBYH8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1524256071</pqid></control><display><type>article</type><title>Effectiveness of trivalent flu vaccine in healthy young children</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Blyth, Christopher C ; Jacoby, Peter ; Effler, Paul V ; Kelly, Heath ; Smith, David W ; Robins, Christine ; Willis, Gabriela A ; Levy, Avram ; Keil, Anthony D ; Richmond, Peter C</creator><creatorcontrib>Blyth, Christopher C ; Jacoby, Peter ; Effler, Paul V ; Kelly, Heath ; Smith, David W ; Robins, Christine ; Willis, Gabriela A ; Levy, Avram ; Keil, Anthony D ; Richmond, Peter C ; WAIVE Study Team</creatorcontrib><description>There are few studies evaluating the effectiveness of trivalent influenza vaccination (TIV) in young children, particularly in children <2 years. The Western Australian Influenza Vaccine Effectiveness Study commenced in 2008 to evaluate a program providing TIV to children aged 6 to 59 months.
An observational study enrolling children with influenza-like illness presenting to a tertiary pediatric hospital was conducted (2008-2012). Vaccination status was determined by parental questionnaire and confirmed via the national immunization register and/or vaccine providers. Respiratory virus polymerase chain reaction and culture were performed on nasopharyngeal samples. The test-negative design was used to estimate vaccine effectiveness (VE) by using 2 control groups: all influenza test-negative subjects and other-virus-detected (OVD) subjects. Adjusted odds ratios were estimated from models with season, month of disease onset, age, gender, indigenous status, prematurity, and comorbidities as covariates. Subjects enrolled in 2009 were excluded from VE calculations.
Of 2001 children enrolled, influenza was identified in 389 (20.4%) children. Another respiratory virus was identified in 1134 (59.6%) children. Overall, 295 of 1903 (15.5%) children were fully vaccinated and 161 of 1903 (8.4%) children were partially vaccinated. Vaccine uptake was significantly lower in 2010-2012 after increased febrile adverse events observed in 2010. Using test-negative controls, VE was 64.7% (95% confidence interval [CI]: 33.7%-81.2%). No difference in VE was observed with OVD controls (65.8%; 95% CI: 32.1%-82.8%). The VE for children <2 years was 85.8% (95% CI: 37.9%-96.7%).
This study reveals the effectiveness of TIV in young children over 4 seasons by using test-negative and OVD controls. TIV was effective in children aged <2 years. Despite demonstrated vaccine effectiveness, uptake of TIV remains suboptimal.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2013-3707</identifier><identifier>PMID: 24753525</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Antibodies, Viral - blood ; Child, Preschool ; Children ; Children & youth ; Disease control ; Effectiveness studies ; Evaluation ; Female ; Health aspects ; Humans ; Immunization ; Immunization, Secondary ; Infant ; Influenza ; Influenza vaccines ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - immunology ; Influenza, Human - immunology ; Influenza, Human - prevention & control ; Male ; Pediatrics ; Treatment Outcome ; Western Australia</subject><ispartof>Pediatrics (Evanston), 2014-05, Vol.133 (5), p.e1218-e1225</ispartof><rights>Copyright © 2014 by the American Academy of Pediatrics.</rights><rights>Copyright American Academy of Pediatrics May 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-e8364e6059d5ee95d42b7d3d5f4083a3e7e6623963e32d46ec03005b85492c413</citedby><cites>FETCH-LOGICAL-c361t-e8364e6059d5ee95d42b7d3d5f4083a3e7e6623963e32d46ec03005b85492c413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24753525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blyth, Christopher C</creatorcontrib><creatorcontrib>Jacoby, Peter</creatorcontrib><creatorcontrib>Effler, Paul V</creatorcontrib><creatorcontrib>Kelly, Heath</creatorcontrib><creatorcontrib>Smith, David W</creatorcontrib><creatorcontrib>Robins, Christine</creatorcontrib><creatorcontrib>Willis, Gabriela A</creatorcontrib><creatorcontrib>Levy, Avram</creatorcontrib><creatorcontrib>Keil, Anthony D</creatorcontrib><creatorcontrib>Richmond, Peter C</creatorcontrib><creatorcontrib>WAIVE Study Team</creatorcontrib><title>Effectiveness of trivalent flu vaccine in healthy young children</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>There are few studies evaluating the effectiveness of trivalent influenza vaccination (TIV) in young children, particularly in children <2 years. The Western Australian Influenza Vaccine Effectiveness Study commenced in 2008 to evaluate a program providing TIV to children aged 6 to 59 months.
An observational study enrolling children with influenza-like illness presenting to a tertiary pediatric hospital was conducted (2008-2012). Vaccination status was determined by parental questionnaire and confirmed via the national immunization register and/or vaccine providers. Respiratory virus polymerase chain reaction and culture were performed on nasopharyngeal samples. The test-negative design was used to estimate vaccine effectiveness (VE) by using 2 control groups: all influenza test-negative subjects and other-virus-detected (OVD) subjects. Adjusted odds ratios were estimated from models with season, month of disease onset, age, gender, indigenous status, prematurity, and comorbidities as covariates. Subjects enrolled in 2009 were excluded from VE calculations.
Of 2001 children enrolled, influenza was identified in 389 (20.4%) children. Another respiratory virus was identified in 1134 (59.6%) children. Overall, 295 of 1903 (15.5%) children were fully vaccinated and 161 of 1903 (8.4%) children were partially vaccinated. Vaccine uptake was significantly lower in 2010-2012 after increased febrile adverse events observed in 2010. Using test-negative controls, VE was 64.7% (95% confidence interval [CI]: 33.7%-81.2%). No difference in VE was observed with OVD controls (65.8%; 95% CI: 32.1%-82.8%). The VE for children <2 years was 85.8% (95% CI: 37.9%-96.7%).
This study reveals the effectiveness of TIV in young children over 4 seasons by using test-negative and OVD controls. TIV was effective in children aged <2 years. Despite demonstrated vaccine effectiveness, uptake of TIV remains suboptimal.</description><subject>Antibodies, Viral - blood</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Disease control</subject><subject>Effectiveness studies</subject><subject>Evaluation</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization, Secondary</subject><subject>Infant</subject><subject>Influenza</subject><subject>Influenza vaccines</subject><subject>Influenza Vaccines - administration & dosage</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza, Human - immunology</subject><subject>Influenza, Human - prevention & control</subject><subject>Male</subject><subject>Pediatrics</subject><subject>Treatment Outcome</subject><subject>Western Australia</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkT1PwzAQhi0EgvKxMqJILCwpZ5_tJBuo4kuqxAKzlTqXNsh1SpxU9N_jqMDAcrc8d3ruXsYuOUy5kuJ2Q1WYCuCYYgbZAZtwKPJUikwdsgkA8lQCqBN2GsIHAEiViWN2ImSmUAk1YXcPdU22b7bkKYSkrZO-a7alI98ntRuSbWlt4ylpfLKi0vWrXbJrB79M7KpxVUf-nB3VpQt08dPP2Pvjw9vsOZ2_Pr3M7uepRc37lHLUkjSoolJEhaqkWGQVVqqWkGOJlJHWAguNhKKSmixgFF_kShbCSo5n7Ga_d9O1nwOF3qybYMm50lM7BMNVrjlwIVVEr_-hH-3Q-WgXKSGF0pCNC9M9tYzXmsbb1vf01dvWOVqSifKzV3OPOlcoY438dM_brg2ho9psumZddjvDwYxZmDELM2ZhxiziwNWPxrBYU_WH_z4fvwFJBYH8</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Blyth, Christopher C</creator><creator>Jacoby, Peter</creator><creator>Effler, Paul V</creator><creator>Kelly, Heath</creator><creator>Smith, David W</creator><creator>Robins, Christine</creator><creator>Willis, Gabriela A</creator><creator>Levy, Avram</creator><creator>Keil, Anthony D</creator><creator>Richmond, Peter C</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20140501</creationdate><title>Effectiveness of trivalent flu vaccine in healthy young children</title><author>Blyth, Christopher C ; Jacoby, Peter ; Effler, Paul V ; Kelly, Heath ; Smith, David W ; Robins, Christine ; Willis, Gabriela A ; Levy, Avram ; Keil, Anthony D ; Richmond, Peter C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-e8364e6059d5ee95d42b7d3d5f4083a3e7e6623963e32d46ec03005b85492c413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antibodies, Viral - blood</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>Disease control</topic><topic>Effectiveness studies</topic><topic>Evaluation</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization, Secondary</topic><topic>Infant</topic><topic>Influenza</topic><topic>Influenza vaccines</topic><topic>Influenza Vaccines - administration & dosage</topic><topic>Influenza Vaccines - immunology</topic><topic>Influenza, Human - immunology</topic><topic>Influenza, Human - prevention & control</topic><topic>Male</topic><topic>Pediatrics</topic><topic>Treatment Outcome</topic><topic>Western Australia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blyth, Christopher C</creatorcontrib><creatorcontrib>Jacoby, Peter</creatorcontrib><creatorcontrib>Effler, Paul V</creatorcontrib><creatorcontrib>Kelly, Heath</creatorcontrib><creatorcontrib>Smith, David W</creatorcontrib><creatorcontrib>Robins, Christine</creatorcontrib><creatorcontrib>Willis, Gabriela A</creatorcontrib><creatorcontrib>Levy, Avram</creatorcontrib><creatorcontrib>Keil, Anthony D</creatorcontrib><creatorcontrib>Richmond, Peter C</creatorcontrib><creatorcontrib>WAIVE Study Team</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blyth, Christopher C</au><au>Jacoby, Peter</au><au>Effler, Paul V</au><au>Kelly, Heath</au><au>Smith, David W</au><au>Robins, Christine</au><au>Willis, Gabriela A</au><au>Levy, Avram</au><au>Keil, Anthony D</au><au>Richmond, Peter C</au><aucorp>WAIVE Study Team</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of trivalent flu vaccine in healthy young children</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>133</volume><issue>5</issue><spage>e1218</spage><epage>e1225</epage><pages>e1218-e1225</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>There are few studies evaluating the effectiveness of trivalent influenza vaccination (TIV) in young children, particularly in children <2 years. The Western Australian Influenza Vaccine Effectiveness Study commenced in 2008 to evaluate a program providing TIV to children aged 6 to 59 months.
An observational study enrolling children with influenza-like illness presenting to a tertiary pediatric hospital was conducted (2008-2012). Vaccination status was determined by parental questionnaire and confirmed via the national immunization register and/or vaccine providers. Respiratory virus polymerase chain reaction and culture were performed on nasopharyngeal samples. The test-negative design was used to estimate vaccine effectiveness (VE) by using 2 control groups: all influenza test-negative subjects and other-virus-detected (OVD) subjects. Adjusted odds ratios were estimated from models with season, month of disease onset, age, gender, indigenous status, prematurity, and comorbidities as covariates. Subjects enrolled in 2009 were excluded from VE calculations.
Of 2001 children enrolled, influenza was identified in 389 (20.4%) children. Another respiratory virus was identified in 1134 (59.6%) children. Overall, 295 of 1903 (15.5%) children were fully vaccinated and 161 of 1903 (8.4%) children were partially vaccinated. Vaccine uptake was significantly lower in 2010-2012 after increased febrile adverse events observed in 2010. Using test-negative controls, VE was 64.7% (95% confidence interval [CI]: 33.7%-81.2%). No difference in VE was observed with OVD controls (65.8%; 95% CI: 32.1%-82.8%). The VE for children <2 years was 85.8% (95% CI: 37.9%-96.7%).
This study reveals the effectiveness of TIV in young children over 4 seasons by using test-negative and OVD controls. TIV was effective in children aged <2 years. Despite demonstrated vaccine effectiveness, uptake of TIV remains suboptimal.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>24753525</pmid><doi>10.1542/peds.2013-3707</doi></addata></record> |
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| subjects | Antibodies, Viral - blood Child, Preschool Children Children & youth Disease control Effectiveness studies Evaluation Female Health aspects Humans Immunization Immunization, Secondary Infant Influenza Influenza vaccines Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control Male Pediatrics Treatment Outcome Western Australia |
| title | Effectiveness of trivalent flu vaccine in healthy young children |
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