Shedding of epithin/PRSS14 is induced by TGF-β and mediated by tumor necrosis factor-α converting enzyme

•TGF-β induces rapid epithin/PRSS14 shedding through receptor mediated pathway.•TACE mediates the TGF-β-dependent shedding of epithin/PRSS14.•TGF-β induces translocation of intracellular pool of TACE to the membrane. Epithin/PRSS14, a type II transmembrane serine protease, plays critical roles in ca...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-10, Vol.452 (4), p.1084-1090
Hauptverfasser:	Lee, Hyo Seon, Park, Bo Mi, Cho, Youngkyung, Kim, Sauryang, Kim, Chungho, Kim, Moon Gyo, Park, Dongeun
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAM17 Protein Animals Cell Line Cell Membrane - metabolism Ectodomain shedding Epithelial Cells - metabolism Epithin Membrane Proteins - metabolism Mice Protein Transport - physiology Serine Endopeptidases - metabolism TGF-β Transforming Growth Factor beta - metabolism Tumor necrosis factor-α converting enzyme (TACE)
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