Population pharmacokinetics of maslinic acid, a triterpene from olives, after intravenous and oral administration in rats

SCOPE: Maslinic acid is a bioactive minor component of Olea europaea L. with health‐enhancing activities and no harmful effects. A pharmacokinetic (PK) study was conducted to determine its bioavailability for future studies of maslinic acid in humans. METHODS AND RESULTS: Intravenous (1 mg/kg) and o...

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Veröffentlicht in:	Molecular nutrition & food research 2014-10, Vol.58 (10), p.1970-1979
Hauptverfasser:	Sánchez‐González, Marta, Colom, Helena, Lozano‐Mena, Glòria, Juan, M. Emília, Planas, Joana M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - blood Antineoplastic Agents, Phytogenic - economics Antineoplastic Agents, Phytogenic - pharmacokinetics bioactive properties bioavailability Biological and medical sciences Biological Availability blood blood flow Body Weight Dietary Supplements Drug Stability excretion Feeding. Feeding behavior Food-Processing Industry - economics Fruit - chemistry Fundamental and applied biological sciences. Psychology HPLC-MS humans Industrial Waste - analysis Industrial Waste - economics Injections, Intravenous Intestinal Absorption intravenous injection Male Maslinic acid Metabolic Clearance Rate Models, Biological Olea - chemistry Olea europaea olives oral administration Oral bioavailability Pentacyclic triterpenes pharmacokinetics Rat plasma rats Rats, Sprague-Dawley Renal Elimination Tissue Distribution Triterpenes - administration & dosage Triterpenes - blood Triterpenes - economics Triterpenes - pharmacokinetics triterpenoids Vertebrates: anatomy and physiology, studies on body, several organs or systems
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