Contribution of Glucose to Crystallization of Phenytoin in Injectable Dosage Form by Dilution with Infusion Fluids
The crystallization of phenytoin occurring after its dilution with infusion fluid is a major concern in the clinical use of injectable phenytoin. To gain further understanding of the crystallization, this study assessed details of the involvement of glucose in this action. For sample preparation, ph...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2014/10/01, Vol.62(10), pp.989-993 |
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| creator | Onuki, Yoshinori Hasegawa, Naoki Ikegami-Kawai, Mayumi Suematsu, Takako Sakurai, Satoshi Shirozu, Shunsuke Tsubuki, Masayoshi Obata, Yasuko Takayama, Kozo |
| description | The crystallization of phenytoin occurring after its dilution with infusion fluid is a major concern in the clinical use of injectable phenytoin. To gain further understanding of the crystallization, this study assessed details of the involvement of glucose in this action. For sample preparation, phenytoin crystals were created by diluting the injectable phenytoin with infusion fluids with different glucose concentrations at different temperature, and then the characteristics of the crystallization (e.g., crystal size in the long direction, accumulated amount over 24 h, and crystallization rate constant) were measured. Results of the analysis of variance indicated that the glucose concentration and temperature had significant impacts on the crystallization. The mode of action of the glucose concentration was suggested to be different from that of the incubation temperature. This study also examined the molecular mobility of components (i.e., glucose, propylene glycol, phenytoin) in the admixtures using diffusion NMR techniques. The findings will provide valuable information for the clinical use of injectable phenytoin. |
| doi_str_mv | 10.1248/cpb.c14-00353 |
| format | Article |
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To gain further understanding of the crystallization, this study assessed details of the involvement of glucose in this action. For sample preparation, phenytoin crystals were created by diluting the injectable phenytoin with infusion fluids with different glucose concentrations at different temperature, and then the characteristics of the crystallization (e.g., crystal size in the long direction, accumulated amount over 24 h, and crystallization rate constant) were measured. Results of the analysis of variance indicated that the glucose concentration and temperature had significant impacts on the crystallization. The mode of action of the glucose concentration was suggested to be different from that of the incubation temperature. This study also examined the molecular mobility of components (i.e., glucose, propylene glycol, phenytoin) in the admixtures using diffusion NMR techniques. The findings will provide valuable information for the clinical use of injectable phenytoin.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.c14-00353</identifier><identifier>PMID: 25273057</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Crystallization ; crystallization characteristic ; diffusion coefficient ; Glucose - chemistry ; glucose infusion fluid ; Johnson–Mehl–Avrami model ; Kinetics ; Magnetic Resonance Spectroscopy ; phenytoin ; Phenytoin - chemistry ; Propylene Glycol - chemistry ; Solubility ; Temperature</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2014/10/01, Vol.62(10), pp.989-993</ispartof><rights>2014 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c467t-87d478a81e7f299c664a669dd979cb58e57f22a5e2a367322359136a21b498f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25273057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Onuki, Yoshinori</creatorcontrib><creatorcontrib>Hasegawa, Naoki</creatorcontrib><creatorcontrib>Ikegami-Kawai, Mayumi</creatorcontrib><creatorcontrib>Suematsu, Takako</creatorcontrib><creatorcontrib>Sakurai, Satoshi</creatorcontrib><creatorcontrib>Shirozu, Shunsuke</creatorcontrib><creatorcontrib>Tsubuki, Masayoshi</creatorcontrib><creatorcontrib>Obata, Yasuko</creatorcontrib><creatorcontrib>Takayama, Kozo</creatorcontrib><title>Contribution of Glucose to Crystallization of Phenytoin in Injectable Dosage Form by Dilution with Infusion Fluids</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>The crystallization of phenytoin occurring after its dilution with infusion fluid is a major concern in the clinical use of injectable phenytoin. To gain further understanding of the crystallization, this study assessed details of the involvement of glucose in this action. For sample preparation, phenytoin crystals were created by diluting the injectable phenytoin with infusion fluids with different glucose concentrations at different temperature, and then the characteristics of the crystallization (e.g., crystal size in the long direction, accumulated amount over 24 h, and crystallization rate constant) were measured. Results of the analysis of variance indicated that the glucose concentration and temperature had significant impacts on the crystallization. The mode of action of the glucose concentration was suggested to be different from that of the incubation temperature. This study also examined the molecular mobility of components (i.e., glucose, propylene glycol, phenytoin) in the admixtures using diffusion NMR techniques. The findings will provide valuable information for the clinical use of injectable phenytoin.</description><subject>Crystallization</subject><subject>crystallization characteristic</subject><subject>diffusion coefficient</subject><subject>Glucose - chemistry</subject><subject>glucose infusion fluid</subject><subject>Johnson–Mehl–Avrami model</subject><subject>Kinetics</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>phenytoin</subject><subject>Phenytoin - chemistry</subject><subject>Propylene Glycol - chemistry</subject><subject>Solubility</subject><subject>Temperature</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1vFCEYh4nR2G316NWQePEylY8BhqPZddsmTfSgZ8Iw73TZsMMKTJr1r5fttmtiQiDwPnmA94fQB0quKWu7L27fXzvaNoRwwV-hBeWtagRj_DVaEEJ0w7jkF-gy5y0hTBDF36ILJpjiRKgFSss4leT7ufg44TjimzC7mAGXiJfpkIsNwf-xL9UfG5gOJfoJ13E3bcEV2wfAq5jtA-B1TDvcH_DKh5Pw0ZdN5cY5H3frMPshv0NvRhsyvH9er9Cv9befy9vm_vvN3fLrfeNaqUrTqaFVne0oqJFp7aRsrZR6GLTSrhcdiHrOrABmuVS8_lhoyqVltG91N3J-hT6fvPsUf8-Qi9n57CAEO0Gcs6Gik0QLLWVFP_2HbuOcpvq6StVLeUf4kWpOlEsx5wSj2Se_s-lgKDHHMEwNw9QwzFMYlf_4bJ37HQxn-qX7FVidgG3t8wOcAZuKdwGedJId7XU-e_-VNzYZmPhfxK2dAQ</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Onuki, Yoshinori</creator><creator>Hasegawa, Naoki</creator><creator>Ikegami-Kawai, Mayumi</creator><creator>Suematsu, Takako</creator><creator>Sakurai, Satoshi</creator><creator>Shirozu, Shunsuke</creator><creator>Tsubuki, Masayoshi</creator><creator>Obata, Yasuko</creator><creator>Takayama, Kozo</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>Contribution of Glucose to Crystallization of Phenytoin in Injectable Dosage Form by Dilution with Infusion Fluids</title><author>Onuki, Yoshinori ; Hasegawa, Naoki ; Ikegami-Kawai, Mayumi ; Suematsu, Takako ; Sakurai, Satoshi ; Shirozu, Shunsuke ; Tsubuki, Masayoshi ; Obata, Yasuko ; Takayama, Kozo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-87d478a81e7f299c664a669dd979cb58e57f22a5e2a367322359136a21b498f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Crystallization</topic><topic>crystallization characteristic</topic><topic>diffusion coefficient</topic><topic>Glucose - chemistry</topic><topic>glucose infusion fluid</topic><topic>Johnson–Mehl–Avrami model</topic><topic>Kinetics</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>phenytoin</topic><topic>Phenytoin - chemistry</topic><topic>Propylene Glycol - chemistry</topic><topic>Solubility</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Onuki, Yoshinori</creatorcontrib><creatorcontrib>Hasegawa, Naoki</creatorcontrib><creatorcontrib>Ikegami-Kawai, Mayumi</creatorcontrib><creatorcontrib>Suematsu, Takako</creatorcontrib><creatorcontrib>Sakurai, Satoshi</creatorcontrib><creatorcontrib>Shirozu, Shunsuke</creatorcontrib><creatorcontrib>Tsubuki, Masayoshi</creatorcontrib><creatorcontrib>Obata, Yasuko</creatorcontrib><creatorcontrib>Takayama, Kozo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Onuki, Yoshinori</au><au>Hasegawa, Naoki</au><au>Ikegami-Kawai, Mayumi</au><au>Suematsu, Takako</au><au>Sakurai, Satoshi</au><au>Shirozu, Shunsuke</au><au>Tsubuki, Masayoshi</au><au>Obata, Yasuko</au><au>Takayama, Kozo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of Glucose to Crystallization of Phenytoin in Injectable Dosage Form by Dilution with Infusion Fluids</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>62</volume><issue>10</issue><spage>989</spage><epage>993</epage><pages>989-993</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>The crystallization of phenytoin occurring after its dilution with infusion fluid is a major concern in the clinical use of injectable phenytoin. To gain further understanding of the crystallization, this study assessed details of the involvement of glucose in this action. For sample preparation, phenytoin crystals were created by diluting the injectable phenytoin with infusion fluids with different glucose concentrations at different temperature, and then the characteristics of the crystallization (e.g., crystal size in the long direction, accumulated amount over 24 h, and crystallization rate constant) were measured. Results of the analysis of variance indicated that the glucose concentration and temperature had significant impacts on the crystallization. The mode of action of the glucose concentration was suggested to be different from that of the incubation temperature. This study also examined the molecular mobility of components (i.e., glucose, propylene glycol, phenytoin) in the admixtures using diffusion NMR techniques. The findings will provide valuable information for the clinical use of injectable phenytoin.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>25273057</pmid><doi>10.1248/cpb.c14-00353</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Crystallization crystallization characteristic diffusion coefficient Glucose - chemistry glucose infusion fluid Johnson–Mehl–Avrami model Kinetics Magnetic Resonance Spectroscopy phenytoin Phenytoin - chemistry Propylene Glycol - chemistry Solubility Temperature |
| title | Contribution of Glucose to Crystallization of Phenytoin in Injectable Dosage Form by Dilution with Infusion Fluids |
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