The changing face of the molecular evolutionary clock
•Genomic data have provided valuable insights into the molecular clock.•Genome sequences offer exciting prospects for estimating evolutionary timescales.•Placing a timescale on the Tree of Life relies on accurate models of rate variation. The molecular clock has played an important role in biologica...
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| Veröffentlicht in: | Trends in ecology & evolution (Amsterdam) 2014-09, Vol.29 (9), p.496-503 |
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| container_title | Trends in ecology & evolution (Amsterdam) |
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| creator | Ho, Simon Y.W. |
| description | •Genomic data have provided valuable insights into the molecular clock.•Genome sequences offer exciting prospects for estimating evolutionary timescales.•Placing a timescale on the Tree of Life relies on accurate models of rate variation.
The molecular clock has played an important role in biological research, both as a description of the evolutionary process and as a tool for inferring evolutionary timescales. Genomic data have provided valuable insights into the molecular clock, allowing the patterns and causes of evolutionary rate variation to be characterized in increasing detail. I explain how genome sequences offer exciting opportunities for estimating the timescale of the Tree of Life. I describe the different approaches that have been used to deal with the computational and statistical challenges encountered in molecular clock analyses of genomic data. Finally, I offer a perspective on the future of molecular clocks, highlighting some of the key limitations and the most promising research directions. |
| doi_str_mv | 10.1016/j.tree.2014.07.004 |
| format | Article |
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The molecular clock has played an important role in biological research, both as a description of the evolutionary process and as a tool for inferring evolutionary timescales. Genomic data have provided valuable insights into the molecular clock, allowing the patterns and causes of evolutionary rate variation to be characterized in increasing detail. I explain how genome sequences offer exciting opportunities for estimating the timescale of the Tree of Life. I describe the different approaches that have been used to deal with the computational and statistical challenges encountered in molecular clock analyses of genomic data. Finally, I offer a perspective on the future of molecular clocks, highlighting some of the key limitations and the most promising research directions.</description><subject>Animal and plant ecology</subject><subject>Animal, plant and microbial ecology</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Biological evolution</subject><subject>Conservation, protection and management of environment and wildlife</subject><subject>Evolution, Molecular</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Genetic Drift</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>genomic data</subject><subject>Genomics</subject><subject>Models, Genetic</subject><subject>molecular clock</subject><subject>Mutation Rate</subject><subject>pacemaker models</subject><subject>phylogenetic analysis</subject><subject>Phylogeny</subject><subject>rate heterogeneity</subject><subject>Sequence Analysis, DNA</subject><issn>0169-5347</issn><issn>1872-8383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFL7DAQx4Mouk_9Ah6kF8FLa9KkSQpeRPQ9QfCi55BOJ5q122jSCn57s-yqtzeXgeE3M39-hJwwWjHK5MWymiJiVVMmKqoqSsUOWTCt6lJzzXfJIkNt2XChDsiflJY0VyvafXJQN1RLKfWCNI8vWMCLHZ_9-Fw4C1gEV0x5uAoDwjzYWOBHGObJh9HGzwKGAK9HZM_ZIeHxth-Sp9ubx-t_5f3D37vrq_sShG6mUreOd5xJ7LkSHDl0QlBXg7Q9tqLrkEmhpJaqqy0wqC3rFJeOoWupVULyQ3K-ufsWw_uMaTIrnwCHwY4Y5mRYoyVtG61ZRusNCjGkFNGZt-hXObFh1Kx1maVZ6zJrXYYqk3XlpdPt_blbYf-z8u0nA2dbwCawg4t2BJ9-uSy70Wz9_XLDYbbx4TGaBB5HwN5HhMn0wf8vxxcDVoec</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Ho, Simon Y.W.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>The changing face of the molecular evolutionary clock</title><author>Ho, Simon Y.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-89f3b316ed3743e3cb440f2c6ade94bbe16476867b2ac1c2a1b736f1ef90a7463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animal and plant ecology</topic><topic>Animal, plant and microbial ecology</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Biological evolution</topic><topic>Conservation, protection and management of environment and wildlife</topic><topic>Evolution, Molecular</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Genetic Drift</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>genomic data</topic><topic>Genomics</topic><topic>Models, Genetic</topic><topic>molecular clock</topic><topic>Mutation Rate</topic><topic>pacemaker models</topic><topic>phylogenetic analysis</topic><topic>Phylogeny</topic><topic>rate heterogeneity</topic><topic>Sequence Analysis, DNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ho, Simon Y.W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in ecology & evolution (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ho, Simon Y.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The changing face of the molecular evolutionary clock</atitle><jtitle>Trends in ecology & evolution (Amsterdam)</jtitle><addtitle>Trends Ecol Evol</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>29</volume><issue>9</issue><spage>496</spage><epage>503</epage><pages>496-503</pages><issn>0169-5347</issn><eissn>1872-8383</eissn><abstract>•Genomic data have provided valuable insights into the molecular clock.•Genome sequences offer exciting prospects for estimating evolutionary timescales.•Placing a timescale on the Tree of Life relies on accurate models of rate variation.
The molecular clock has played an important role in biological research, both as a description of the evolutionary process and as a tool for inferring evolutionary timescales. Genomic data have provided valuable insights into the molecular clock, allowing the patterns and causes of evolutionary rate variation to be characterized in increasing detail. I explain how genome sequences offer exciting opportunities for estimating the timescale of the Tree of Life. I describe the different approaches that have been used to deal with the computational and statistical challenges encountered in molecular clock analyses of genomic data. Finally, I offer a perspective on the future of molecular clocks, highlighting some of the key limitations and the most promising research directions.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>25086668</pmid><doi>10.1016/j.tree.2014.07.004</doi><tpages>8</tpages></addata></record> |
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| ispartof | Trends in ecology & evolution (Amsterdam), 2014-09, Vol.29 (9), p.496-503 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animal and plant ecology Animal, plant and microbial ecology Applied ecology Biological and medical sciences Biological evolution Conservation, protection and management of environment and wildlife Evolution, Molecular Fundamental and applied biological sciences. Psychology General aspects Genetic Drift Genetics of eukaryotes. Biological and molecular evolution genomic data Genomics Models, Genetic molecular clock Mutation Rate pacemaker models phylogenetic analysis Phylogeny rate heterogeneity Sequence Analysis, DNA |
| title | The changing face of the molecular evolutionary clock |
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