Tumor Microvasculature Characteristics Studied by Image Analysis: Histologically-Driven Angiogenic Profile
Angiogenesis, a hallmark of cancer, has been studied to be a potential marker for diagnosis, prognosis and therapy in breast cancer. To evaluate tumor angiogenesis, histological assessment has been a common approach and counting tumor microvessels after visualizing them by immunohistochemistry has b...
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| Veröffentlicht in: | The International Journal of Biological Markers 2014-07, Vol.29 (3), p.204-207 |
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| container_title | The International Journal of Biological Markers |
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| creator | Fakhrejahani, Elham Asao, Yasufumi Toi, Masakazu |
| description | Angiogenesis, a hallmark of cancer, has been studied to be a potential marker for diagnosis, prognosis and therapy in breast cancer. To evaluate tumor angiogenesis, histological assessment has been a common approach and counting tumor microvessels after visualizing them by immunohistochemistry has been in use for a long time. With recent advances in digital pathology and image analysis, other characteristics of tumor vasculature can also be evaluated. In this article we briefly review the potentials of image analysis in assessing tumor microvessel morphologically that might be helpful in defining a better angiogenesis marker than other common markers like vessel count. |
| doi_str_mv | 10.5301/jbm.5000098 |
| format | Article |
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| subjects | Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Breast Neoplasms - blood supply Breast Neoplasms - metabolism Breast Neoplasms - pathology Female Humans Image Processing, Computer-Assisted - methods Immunohistochemistry Microvessels - metabolism Microvessels - pathology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Prognosis |
| title | Tumor Microvasculature Characteristics Studied by Image Analysis: Histologically-Driven Angiogenic Profile |
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