Isolation and structure of leukotriene-A sub(4) hydrolase inhibitor: 8(S)-amino-2(R)-methyl-7-oxononanoic acid produced by Streptomyces diastaticus

The novel amino acid 8(S)-amino-2(R)-methyl-7-oxononanoic acid (1) was isolated from the soil-borne microorganism Streptomyces diastaticus during our screening for inhibitors of leukotriene-A sub(4) hydrolase (LTA sub(4)H), a requisite enzyme in the biosynthesis of the potent inflammatory mediator l...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1996-01, Vol.59, p.962-964
Hauptverfasser:	Parnas, B L, Durley, R C, Rhoden, EE, Kilpatrick, B F, Makkar, N, Thomas, KE, Smith, W G, Corley, D G
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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