Inhibition of testicular steroidogenesis in 2,3,7,8-tetrachlorodibenzo- p-dioxin-treated rats: Evidence that the key lesion occurs prior to or during pregnenolone formation

The mechanism by which 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) treatment decreases testosterone (T) secretion without significantly altering plasma luteinizing hormone (LH) concentrations was investigated. Testes from sexually mature Sprague-Dawley rats dosed 7 days earlier with 100 μg TCDD/kg s...

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Veröffentlicht in:	Toxicology and applied pharmacology 1990-10, Vol.106 (1), p.112-125
Hauptverfasser:	Kleeman, James M., Moore, Robert W., Peterson, Richard E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Weight - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Chorionic Gonadotropin - pharmacology Eating - drug effects Female Hemodynamics - drug effects Luteinizing Hormone - pharmacology Male Medical sciences Organ Size - drug effects Polychlorinated Dibenzodioxins - toxicity Pregnenolone - biosynthesis Rats Rats, Inbred Strains Testis - drug effects Testis - metabolism Testosterone - biosynthesis Toxicology Various organic compounds
Online-Zugang:	Volltext
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