Pulmonary effects in rats inhaling size-separated chrysotile asbestos fibres or p-aramid fibrils: differences in cellular proliferative responses
This study was designed to compare the pulmonary cellular proliferative effects of inhaled, size-separated preparations of chrysotile asbestos fibres with similar aerosol fibre concentrations of para-aramid fibrils. Following fibre preparation, rats were exposed for 2 weeks to aerosols of p-aramid f...
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| Veröffentlicht in: | Toxicology letters 1996-11, Vol.88 (1), p.287-292 |
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| creator | Warheit, David B. Hartsky, Mark A. Frame, Steven R. |
| description | This study was designed to compare the pulmonary cellular proliferative effects of inhaled, size-separated preparations of chrysotile asbestos fibres with similar aerosol fibre concentrations of
para-aramid fibrils. Following fibre preparation, rats were exposed for 2 weeks to aerosols of
p-aramid fibrils or chrysotile asbestos fibres at design fibre concentrations of 750 and 400 f/cc. Two week exposures to
p-aramid fibrils produced transient pulmonary inflammatory and cell labeling responses in terminal bronchiolar and subpleural regions. Similar to
p-aramid, exposure to chrysotile produced a transient increase in neutrophils. In contrast, however, substantial increases compared to controls in pulmonary cell labeling indices were measured on terminal bronchiolar, parenchyma!, subpleural, and mesothelial surfaces immediately after exposure, and some increases persisted for 3 months postexposure. In complementary studies we demonstrated that
p-aramid is biodegradable in the lungs of exposed rats; in contrast, the clearance of long chrysotile fibres was slow or insignificant, resulting in a pulmonary retention of long chrysotile asbestos fibres. The dimensional changes of asbestos fibres as well as the pulmonary cell labeling data indicate that chrysotile asbestos fibres may produce greater long-term pulmonary effects when compared to inhaled
para-aramid fibrils. |
| doi_str_mv | 10.1016/0378-4274(96)03751-4 |
| format | Article |
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para-aramid fibrils. Following fibre preparation, rats were exposed for 2 weeks to aerosols of
p-aramid fibrils or chrysotile asbestos fibres at design fibre concentrations of 750 and 400 f/cc. Two week exposures to
p-aramid fibrils produced transient pulmonary inflammatory and cell labeling responses in terminal bronchiolar and subpleural regions. Similar to
p-aramid, exposure to chrysotile produced a transient increase in neutrophils. In contrast, however, substantial increases compared to controls in pulmonary cell labeling indices were measured on terminal bronchiolar, parenchyma!, subpleural, and mesothelial surfaces immediately after exposure, and some increases persisted for 3 months postexposure. In complementary studies we demonstrated that
p-aramid is biodegradable in the lungs of exposed rats; in contrast, the clearance of long chrysotile fibres was slow or insignificant, resulting in a pulmonary retention of long chrysotile asbestos fibres. The dimensional changes of asbestos fibres as well as the pulmonary cell labeling data indicate that chrysotile asbestos fibres may produce greater long-term pulmonary effects when compared to inhaled
para-aramid fibrils.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/0378-4274(96)03751-4</identifier><identifier>PMID: 8920750</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Administration, Inhalation ; Animals ; Asbestos ; Asbestos, Serpentine - administration & dosage ; Asbestos, Serpentine - toxicity ; Biodegradability ; Biodegradation, Environmental ; Carcinogens - administration & dosage ; Carcinogens - toxicity ; Cell Division ; Cell proliferation ; Chrysotile ; Durability ; Fibres ; Inflammation - etiology ; Inflammation - pathology ; Inhaled fibres ; Lung - pathology ; Male ; Mineral Fibers ; Para-aramid ; Particle Size ; Polymers - administration & dosage ; Polymers - toxicity ; Rats</subject><ispartof>Toxicology letters, 1996-11, Vol.88 (1), p.287-292</ispartof><rights>1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-ac1ded10599a6be96311218fcd6e23feb2c820c40b37287c8a7ddaeb7f0f47e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-4274(96)03751-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8920750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Alink, GM (eds)</contributor><contributor>Seemayer, NH</contributor><contributor>Hadnagy, W</contributor><creatorcontrib>Warheit, David B.</creatorcontrib><creatorcontrib>Hartsky, Mark A.</creatorcontrib><creatorcontrib>Frame, Steven R.</creatorcontrib><title>Pulmonary effects in rats inhaling size-separated chrysotile asbestos fibres or p-aramid fibrils: differences in cellular proliferative responses</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>This study was designed to compare the pulmonary cellular proliferative effects of inhaled, size-separated preparations of chrysotile asbestos fibres with similar aerosol fibre concentrations of
para-aramid fibrils. Following fibre preparation, rats were exposed for 2 weeks to aerosols of
p-aramid fibrils or chrysotile asbestos fibres at design fibre concentrations of 750 and 400 f/cc. Two week exposures to
p-aramid fibrils produced transient pulmonary inflammatory and cell labeling responses in terminal bronchiolar and subpleural regions. Similar to
p-aramid, exposure to chrysotile produced a transient increase in neutrophils. In contrast, however, substantial increases compared to controls in pulmonary cell labeling indices were measured on terminal bronchiolar, parenchyma!, subpleural, and mesothelial surfaces immediately after exposure, and some increases persisted for 3 months postexposure. In complementary studies we demonstrated that
p-aramid is biodegradable in the lungs of exposed rats; in contrast, the clearance of long chrysotile fibres was slow or insignificant, resulting in a pulmonary retention of long chrysotile asbestos fibres. The dimensional changes of asbestos fibres as well as the pulmonary cell labeling data indicate that chrysotile asbestos fibres may produce greater long-term pulmonary effects when compared to inhaled
para-aramid fibrils.</description><subject>Administration, Inhalation</subject><subject>Animals</subject><subject>Asbestos</subject><subject>Asbestos, Serpentine - administration & dosage</subject><subject>Asbestos, Serpentine - toxicity</subject><subject>Biodegradability</subject><subject>Biodegradation, Environmental</subject><subject>Carcinogens - administration & dosage</subject><subject>Carcinogens - toxicity</subject><subject>Cell Division</subject><subject>Cell proliferation</subject><subject>Chrysotile</subject><subject>Durability</subject><subject>Fibres</subject><subject>Inflammation - etiology</subject><subject>Inflammation - pathology</subject><subject>Inhaled fibres</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Mineral Fibers</subject><subject>Para-aramid</subject><subject>Particle Size</subject><subject>Polymers - administration & dosage</subject><subject>Polymers - toxicity</subject><subject>Rats</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtRCobAv_ACSfED0E7MSJbQ6VUMWXVAkOvVuOPaZGTrx4kkrlX_CPcXZXPXIazbw3b2beEPKKs3ec8eE966RqRCvFWz1c1qTnjXhCdlxJ3XR80E_J7pHynJwj_mKMDWLoz8iZ0i2TPduRvz_WNOXZlgcKIYBbkMaZFnuIdzbF-SfF-AcahL2tZfDU3ZUHzEtMQC2OgEtGGuJYAGkudN9U2hT9oRQTfqA-VuECs4ODtoOU1mQrs-QUK2KXeA-0tu_zjIAvyLNgE8LLU7wgt58_3V5_bW6-f_l2_fGmcZ1SS2Md9-A567W2wwh66DhvuQrOD9B2AcbWqZY5wcZOtko6ZaX3FkYZWBASugvy5ihb1_i91ivMFHHbzc6QVzS8V0IrxSpRHImuZMQCwexLnKphhjOzPcJsLpvNZaMPSc-NqG2vT_rrOIF_bDo5X_GrIw71xvsIxaCLm0k-lvoG43P8_4B_3lOcbQ</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Warheit, David B.</creator><creator>Hartsky, Mark A.</creator><creator>Frame, Steven R.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19961101</creationdate><title>Pulmonary effects in rats inhaling size-separated chrysotile asbestos fibres or p-aramid fibrils: differences in cellular proliferative responses</title><author>Warheit, David B. ; Hartsky, Mark A. ; Frame, Steven R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-ac1ded10599a6be96311218fcd6e23feb2c820c40b37287c8a7ddaeb7f0f47e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Administration, Inhalation</topic><topic>Animals</topic><topic>Asbestos</topic><topic>Asbestos, Serpentine - administration & dosage</topic><topic>Asbestos, Serpentine - toxicity</topic><topic>Biodegradability</topic><topic>Biodegradation, Environmental</topic><topic>Carcinogens - administration & dosage</topic><topic>Carcinogens - toxicity</topic><topic>Cell Division</topic><topic>Cell proliferation</topic><topic>Chrysotile</topic><topic>Durability</topic><topic>Fibres</topic><topic>Inflammation - etiology</topic><topic>Inflammation - pathology</topic><topic>Inhaled fibres</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>Mineral Fibers</topic><topic>Para-aramid</topic><topic>Particle Size</topic><topic>Polymers - administration & dosage</topic><topic>Polymers - toxicity</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warheit, David B.</creatorcontrib><creatorcontrib>Hartsky, Mark A.</creatorcontrib><creatorcontrib>Frame, Steven R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warheit, David B.</au><au>Hartsky, Mark A.</au><au>Frame, Steven R.</au><au>Alink, GM (eds)</au><au>Seemayer, NH</au><au>Hadnagy, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary effects in rats inhaling size-separated chrysotile asbestos fibres or p-aramid fibrils: differences in cellular proliferative responses</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>88</volume><issue>1</issue><spage>287</spage><epage>292</epage><pages>287-292</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><abstract>This study was designed to compare the pulmonary cellular proliferative effects of inhaled, size-separated preparations of chrysotile asbestos fibres with similar aerosol fibre concentrations of
para-aramid fibrils. Following fibre preparation, rats were exposed for 2 weeks to aerosols of
p-aramid fibrils or chrysotile asbestos fibres at design fibre concentrations of 750 and 400 f/cc. Two week exposures to
p-aramid fibrils produced transient pulmonary inflammatory and cell labeling responses in terminal bronchiolar and subpleural regions. Similar to
p-aramid, exposure to chrysotile produced a transient increase in neutrophils. In contrast, however, substantial increases compared to controls in pulmonary cell labeling indices were measured on terminal bronchiolar, parenchyma!, subpleural, and mesothelial surfaces immediately after exposure, and some increases persisted for 3 months postexposure. In complementary studies we demonstrated that
p-aramid is biodegradable in the lungs of exposed rats; in contrast, the clearance of long chrysotile fibres was slow or insignificant, resulting in a pulmonary retention of long chrysotile asbestos fibres. The dimensional changes of asbestos fibres as well as the pulmonary cell labeling data indicate that chrysotile asbestos fibres may produce greater long-term pulmonary effects when compared to inhaled
para-aramid fibrils.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>8920750</pmid><doi>10.1016/0378-4274(96)03751-4</doi><tpages>6</tpages></addata></record> |
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| ispartof | Toxicology letters, 1996-11, Vol.88 (1), p.287-292 |
| issn | 0378-4274 1879-3169 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Administration, Inhalation Animals Asbestos Asbestos, Serpentine - administration & dosage Asbestos, Serpentine - toxicity Biodegradability Biodegradation, Environmental Carcinogens - administration & dosage Carcinogens - toxicity Cell Division Cell proliferation Chrysotile Durability Fibres Inflammation - etiology Inflammation - pathology Inhaled fibres Lung - pathology Male Mineral Fibers Para-aramid Particle Size Polymers - administration & dosage Polymers - toxicity Rats |
| title | Pulmonary effects in rats inhaling size-separated chrysotile asbestos fibres or p-aramid fibrils: differences in cellular proliferative responses |
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