Persistent elevations in dopamine and its metabolites in the nucleus accumbens after mild subchronic stress in rats with ibotenic acid lesions of the medial prefrontal cortex
This study assessed the possible influence of the medial prefrontal cortex (MPFC) on the response of subcortical dopamine (DA) systems to subchronic, mild stress. DA and its metabolites as well as noradrenaline were assayed in the nucleus accumbens and corpus striatum, 1 and 7 days after one week of...
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| Veröffentlicht in: | Brain research 1990-11, Vol.534 (1), p.321-323 |
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| description | This study assessed the possible influence of the medial prefrontal cortex (MPFC) on the response of subcortical dopamine (DA) systems to subchronic, mild stress. DA and its metabolites as well as noradrenaline were assayed in the nucleus accumbens and corpus striatum, 1 and 7 days after one week of daily intraperitoneal saline injections (Stress) or no handling (NO stress), in rats with sham (Sham) or ibotenic acid (IA) lesions of the MPFC. One day after the last saline injection the level of dihydroxyphenylacetic acid (DOPAC) was elevated in the nucleus accumbens of IA/Stress rats in comparison to the Sham/No stress, Sham/Stress, and IA/No Stress groups. Levels of mesolimbic DA, DOPAC and homovanillic acid were still elevated 7 days after the last injection in IA/Stress animals in comparison to all other groups. There were no other significant differences between the groups. The data suggest that in rats with MPFC impairment, mild subchronic stress can induce alterations in mesolimbic DA activity that persist beyond the duration of the stress. |
| doi_str_mv | 10.1016/0006-8993(90)90149-6 |
| format | Article |
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DA and its metabolites as well as noradrenaline were assayed in the nucleus accumbens and corpus striatum, 1 and 7 days after one week of daily intraperitoneal saline injections (Stress) or no handling (NO stress), in rats with sham (Sham) or ibotenic acid (IA) lesions of the MPFC. One day after the last saline injection the level of dihydroxyphenylacetic acid (DOPAC) was elevated in the nucleus accumbens of IA/Stress rats in comparison to the Sham/No stress, Sham/Stress, and IA/No Stress groups. Levels of mesolimbic DA, DOPAC and homovanillic acid were still elevated 7 days after the last injection in IA/Stress animals in comparison to all other groups. There were no other significant differences between the groups. The data suggest that in rats with MPFC impairment, mild subchronic stress can induce alterations in mesolimbic DA activity that persist beyond the duration of the stress.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(90)90149-6</identifier><identifier>PMID: 2073594</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>3,4-Dihydroxyphenylacetic Acid - metabolism ; Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Catecholamines - metabolism ; Central nervous system ; Cerebral Cortex - drug effects ; Cerebral Cortex - pathology ; Cerebral Cortex - physiology ; Dihydroxyphenylacetic acid ; Dopamine - metabolism ; Fundamental and applied biological sciences. Psychology ; Handling (Psychology) ; Homovanillic Acid - metabolism ; Ibotenic acid ; Ibotenic Acid - toxicity ; Male ; Norepinephrine - metabolism ; Nucleus accumbens ; Nucleus Accumbens - metabolism ; Prefrontal cortex ; Rats ; Rats, Inbred Strains ; Reference Values ; Stress ; Stress, Psychological - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1990-11, Vol.534 (1), p.321-323</ispartof><rights>1990 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-faa29094a171e9740c4373d6daf04d1ddeaac9f1129b6f3022a9ebfcd48a0b8e3</citedby><cites>FETCH-LOGICAL-c418t-faa29094a171e9740c4373d6daf04d1ddeaac9f1129b6f3022a9ebfcd48a0b8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(90)90149-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19401337$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2073594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jaskiw, G.E.</creatorcontrib><creatorcontrib>Karoum, F.K.</creatorcontrib><creatorcontrib>Weinberger, D.R.</creatorcontrib><title>Persistent elevations in dopamine and its metabolites in the nucleus accumbens after mild subchronic stress in rats with ibotenic acid lesions of the medial prefrontal cortex</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>This study assessed the possible influence of the medial prefrontal cortex (MPFC) on the response of subcortical dopamine (DA) systems to subchronic, mild stress. DA and its metabolites as well as noradrenaline were assayed in the nucleus accumbens and corpus striatum, 1 and 7 days after one week of daily intraperitoneal saline injections (Stress) or no handling (NO stress), in rats with sham (Sham) or ibotenic acid (IA) lesions of the MPFC. One day after the last saline injection the level of dihydroxyphenylacetic acid (DOPAC) was elevated in the nucleus accumbens of IA/Stress rats in comparison to the Sham/No stress, Sham/Stress, and IA/No Stress groups. Levels of mesolimbic DA, DOPAC and homovanillic acid were still elevated 7 days after the last injection in IA/Stress animals in comparison to all other groups. There were no other significant differences between the groups. The data suggest that in rats with MPFC impairment, mild subchronic stress can induce alterations in mesolimbic DA activity that persist beyond the duration of the stress.</description><subject>3,4-Dihydroxyphenylacetic Acid - metabolism</subject><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Catecholamines - metabolism</subject><subject>Central nervous system</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebral Cortex - physiology</subject><subject>Dihydroxyphenylacetic acid</subject><subject>Dopamine - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Handling (Psychology)</subject><subject>Homovanillic Acid - metabolism</subject><subject>Ibotenic acid</subject><subject>Ibotenic Acid - toxicity</subject><subject>Male</subject><subject>Norepinephrine - metabolism</subject><subject>Nucleus accumbens</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Prefrontal cortex</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reference Values</subject><subject>Stress</subject><subject>Stress, Psychological - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcuOFCEUJUYz9rT-gSZsNOOiFKroqmIziZn4SibRha7JLbikMRS0QI36U36jdHVn3LnikvO4j0PIM85ec8b7N4yxvhml7K4keyUZF7LpH5ANH4e26VvBHpLNPeUxucz5e_12nWQX5KJlQ7eTYkP-fMGUXS4YCkWPd1BcDJm6QE08wOwCUgiGupLpjAWm6F3BFS97pGHRHpdMQetlnrAKwRZMdHbe0LxMep9icJrmkjCvqgTV6acre-qmWLtWELQz1GNeG0e7Gs9oHHh6SGirQ6mljqngryfkkQWf8en53ZJv7999vfnY3H7-8Onm7W2jBR9LYwFayaQAPnCUg2BadENnegOWCcONQQAtLeetnHrbsbYFiZPVRozAphG7LXl58j2k-GPBXNTsskbvIWBcsuK7UeyE6CtRnIg6xZzruOqQ3Azpt-JMHWNSxwzUMQMlmVpjUkfZ87P_MtVd70XnXCr-4oxD1uBtgqBd_uctBeNdXWlLrk88rMe4c5hU1g6DrudLqIsy0f1_kL8DcbO3</recordid><startdate>19901126</startdate><enddate>19901126</enddate><creator>Jaskiw, G.E.</creator><creator>Karoum, F.K.</creator><creator>Weinberger, D.R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19901126</creationdate><title>Persistent elevations in dopamine and its metabolites in the nucleus accumbens after mild subchronic stress in rats with ibotenic acid lesions of the medial prefrontal cortex</title><author>Jaskiw, G.E. ; Karoum, F.K. ; Weinberger, D.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-faa29094a171e9740c4373d6daf04d1ddeaac9f1129b6f3022a9ebfcd48a0b8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>3,4-Dihydroxyphenylacetic Acid - metabolism</topic><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Catecholamines - metabolism</topic><topic>Central nervous system</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - pathology</topic><topic>Cerebral Cortex - physiology</topic><topic>Dihydroxyphenylacetic acid</topic><topic>Dopamine - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Handling (Psychology)</topic><topic>Homovanillic Acid - metabolism</topic><topic>Ibotenic acid</topic><topic>Ibotenic Acid - toxicity</topic><topic>Male</topic><topic>Norepinephrine - metabolism</topic><topic>Nucleus accumbens</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Prefrontal cortex</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reference Values</topic><topic>Stress</topic><topic>Stress, Psychological - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jaskiw, G.E.</creatorcontrib><creatorcontrib>Karoum, F.K.</creatorcontrib><creatorcontrib>Weinberger, D.R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jaskiw, G.E.</au><au>Karoum, F.K.</au><au>Weinberger, D.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent elevations in dopamine and its metabolites in the nucleus accumbens after mild subchronic stress in rats with ibotenic acid lesions of the medial prefrontal cortex</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1990-11-26</date><risdate>1990</risdate><volume>534</volume><issue>1</issue><spage>321</spage><epage>323</epage><pages>321-323</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>This study assessed the possible influence of the medial prefrontal cortex (MPFC) on the response of subcortical dopamine (DA) systems to subchronic, mild stress. DA and its metabolites as well as noradrenaline were assayed in the nucleus accumbens and corpus striatum, 1 and 7 days after one week of daily intraperitoneal saline injections (Stress) or no handling (NO stress), in rats with sham (Sham) or ibotenic acid (IA) lesions of the MPFC. One day after the last saline injection the level of dihydroxyphenylacetic acid (DOPAC) was elevated in the nucleus accumbens of IA/Stress rats in comparison to the Sham/No stress, Sham/Stress, and IA/No Stress groups. Levels of mesolimbic DA, DOPAC and homovanillic acid were still elevated 7 days after the last injection in IA/Stress animals in comparison to all other groups. There were no other significant differences between the groups. The data suggest that in rats with MPFC impairment, mild subchronic stress can induce alterations in mesolimbic DA activity that persist beyond the duration of the stress.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2073594</pmid><doi>10.1016/0006-8993(90)90149-6</doi><tpages>3</tpages></addata></record> |
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| subjects | 3,4-Dihydroxyphenylacetic Acid - metabolism Animals Biochemistry and metabolism Biological and medical sciences Catecholamines - metabolism Central nervous system Cerebral Cortex - drug effects Cerebral Cortex - pathology Cerebral Cortex - physiology Dihydroxyphenylacetic acid Dopamine - metabolism Fundamental and applied biological sciences. Psychology Handling (Psychology) Homovanillic Acid - metabolism Ibotenic acid Ibotenic Acid - toxicity Male Norepinephrine - metabolism Nucleus accumbens Nucleus Accumbens - metabolism Prefrontal cortex Rats Rats, Inbred Strains Reference Values Stress Stress, Psychological - metabolism Vertebrates: nervous system and sense organs |
| title | Persistent elevations in dopamine and its metabolites in the nucleus accumbens after mild subchronic stress in rats with ibotenic acid lesions of the medial prefrontal cortex |
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