Rat paw-lick/muscle irritation model for evaluating parenteral formulations for pain-on-injection and muscle damage

A two-phase assay was developed in the rat to evaluate parenteral formulations intended for intramuscular administration for the induction of both acute pain-on-injection and delayed pain/discomfort at the injection site (secondary to muscle damage). Phase 1 of the assay assessed pain-on-injection u...

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Veröffentlicht in:	Fundamental and applied toxicology 1990-11, Vol.15 (4), p.697-709
Hauptverfasser:	Chellman, Gary J., Faurot, George F., Lollini, Lance O., McCullough, Tim E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Biological and medical sciences Creatine Kinase - blood Disease Models, Animal Drug toxicity and drugs side effects treatment Hemolysis - drug effects Hemorrhage - chemically induced Hemorrhage - physiopathology Injections, Intramuscular - adverse effects Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Muscular Diseases - chemically induced Muscular Diseases - pathology Necrosis - physiopathology Pain - pathology Pain - psychology Pharmacology. Drug treatments Rats Rats, Inbred Strains
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