TPA induction of EL4 resistance to macrophage-released TNF: Role of ADP-ribosylation in tumoricidal activities of TNF and other factors

Activated macrophages synthesize and release numerous tumoricidal soluble factors that can be divided into receptor- or nonreceptor-dependent agents. Tumor necrosis factor (TNF) would be an example of the former. In our experimental model the killing of EL4 thymoma cells by syngeneic activated macro...

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Veröffentlicht in:	Cellular immunology 1990-04, Vol.127 (1), p.78-91
Hauptverfasser:	Fishman, Marvin, Essani, Naeem, Costlow, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Antibodies - physiology Benzamides - pharmacology Calcimycin - pharmacology Cytotoxicity, Immunologic Cytotoxins - pharmacology Down-Regulation - physiology Genetic Variation Macrophage Activation - drug effects Macrophage Activation - physiology Mice Niacinamide - pharmacology Pertussis Toxin Poly(ADP-ribose) Polymerase Inhibitors Recombinant Proteins - pharmacology Tetradecanoylphorbol Acetate - pharmacology Thymoma - genetics Thymoma - pathology Thymoma - physiopathology Thymus Neoplasms - genetics Thymus Neoplasms - pathology Thymus Neoplasms - physiopathology Tumor Cells, Cultured - pathology Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - physiology Virulence Factors, Bordetella - pharmacology
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