Inhibitory effect of phorbol 12,13-dibutyrate on norepinephrine-induced contraction in rabbit iris dilator muscle

The hypothesis that the increase in Ca 2+ sensitivity on norepinephrine-induced contraction of smooth muscles and also the decrease of the norepinephrine-induced sustained level of intracellular Ca 2+ concentration are produced by the activation of protein kinase C was tested. Phorbol 12,13-dibutyra...

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Veröffentlicht in:	European journal of pharmacology 1996-07, Vol.308 (2), p.145-152
Hauptverfasser:	Satoh, Mitsutoshi, Matsuo, Kazuhiro, Kokubu, Noriko, Takayanagi, Issei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - pharmacology Animals Biological and medical sciences Ca 2+ mobilization Calcium - metabolism Calcium Channel Blockers - pharmacology Dose-Response Relationship, Drug Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology GF 109203X (2-(1-(3-dimethylaminopropyl)-indol-3-yl)-3-(-indol-3-yl)-maleimide) H-7 (1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride) H-88 ( N-(2-cinnamylaminoethyl)-5-isoquinolinesulfonamide) In Vitro Techniques Iris dilator, rabbit Isradipine - pharmacology Male Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - metabolism Norepinephrine - antagonists & inhibitors Norepinephrine - pharmacology Oculomotor Muscles - drug effects Oculomotor Muscles - metabolism Phorbol 12,13-dibutyrate (PDB) Phorbol 12,13-Dibutyrate - pharmacology Protein kinase C Protein Kinase C - metabolism Rabbits Vertebrates: nervous system and sense organs
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