Presence of MHC-I and B-7 molecules in rat and human glioma cells expressing antisense IGF-I mRNA
Tumor cells frequently express the insulin-like growth factor I (IGF-I). Recently we demonstrated that rat glioma cells when transfected with a vector encoding antisense IGF-I cDNA lost tumorigenicity and induced a tumor specific immune response involving CD8+ lymphocytes. Here we show that the cult...
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| Veröffentlicht in: | Neuroscience letters 1996-07, Vol.212 (1), p.9-12 |
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| container_title | Neuroscience letters |
| container_volume | 212 |
| creator | Trojan, Jerzy Duc, Huynh T. Upegui-Gonzalez, L.C. Hor, Frédéric Guo, Yajun Anthony, Donald Ilan, Joseph |
| description | Tumor cells frequently express the insulin-like growth factor I (IGF-I). Recently we demonstrated that rat glioma cells when transfected with a vector encoding antisense IGF-I cDNA lost tumorigenicity and induced a tumor specific immune response involving CD8+ lymphocytes. Here we show that the cultured transfected cell lines, rat C-6 glioma, human primary glioma and mouse teratocarcinoma, expressed an increased level of MHC-I and of co-signaling B-7 molecules. This increased expression of MHC-I and B-7, demonstrated by
51Cr release complement dependent cytoxicity assay and by immunostaining flow cytometry analysis, could contribute to the final immune recognition of glioma immunogenicity. |
| doi_str_mv | 10.1016/0304-3940(96)12770-1 |
| format | Article |
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51Cr release complement dependent cytoxicity assay and by immunostaining flow cytometry analysis, could contribute to the final immune recognition of glioma immunogenicity.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(96)12770-1</identifier><identifier>PMID: 8823750</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Antigens, CD - analysis ; Antisense insulin-like growth factor I ; B-7 ; B7-1 Antigen - analysis ; B7-2 Antigen ; Biological and medical sciences ; Flow Cytometry ; Gene Expression - physiology ; Glioma ; Histocompatibility Antigens Class I - analysis ; Humans ; Insulin-Like Growth Factor I - genetics ; Insulin-Like Growth Factor II - genetics ; Mammalia ; Medical sciences ; Membrane Glycoproteins - analysis ; MHC-I ; Mice ; Neuroblastoma ; Neurology ; Rats ; RNA, Antisense ; RNA, Messenger - metabolism ; Teratocarcinoma ; Transfection ; Tumor Cells, Cultured - chemistry ; Tumor Cells, Cultured - physiology ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Neuroscience letters, 1996-07, Vol.212 (1), p.9-12</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-b9e103049893aa87bb4030d46195f4e664f035873edd5d2791279d6e82428563</citedby><cites>FETCH-LOGICAL-c483t-b9e103049893aa87bb4030d46195f4e664f035873edd5d2791279d6e82428563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0304394096127701$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3155671$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8823750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trojan, Jerzy</creatorcontrib><creatorcontrib>Duc, Huynh T.</creatorcontrib><creatorcontrib>Upegui-Gonzalez, L.C.</creatorcontrib><creatorcontrib>Hor, Frédéric</creatorcontrib><creatorcontrib>Guo, Yajun</creatorcontrib><creatorcontrib>Anthony, Donald</creatorcontrib><creatorcontrib>Ilan, Joseph</creatorcontrib><title>Presence of MHC-I and B-7 molecules in rat and human glioma cells expressing antisense IGF-I mRNA</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Tumor cells frequently express the insulin-like growth factor I (IGF-I). Recently we demonstrated that rat glioma cells when transfected with a vector encoding antisense IGF-I cDNA lost tumorigenicity and induced a tumor specific immune response involving CD8+ lymphocytes. Here we show that the cultured transfected cell lines, rat C-6 glioma, human primary glioma and mouse teratocarcinoma, expressed an increased level of MHC-I and of co-signaling B-7 molecules. This increased expression of MHC-I and B-7, demonstrated by
51Cr release complement dependent cytoxicity assay and by immunostaining flow cytometry analysis, could contribute to the final immune recognition of glioma immunogenicity.</description><subject>Animals</subject><subject>Antigens, CD - analysis</subject><subject>Antisense insulin-like growth factor I</subject><subject>B-7</subject><subject>B7-1 Antigen - analysis</subject><subject>B7-2 Antigen</subject><subject>Biological and medical sciences</subject><subject>Flow Cytometry</subject><subject>Gene Expression - physiology</subject><subject>Glioma</subject><subject>Histocompatibility Antigens Class I - analysis</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I - genetics</subject><subject>Insulin-Like Growth Factor II - genetics</subject><subject>Mammalia</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - analysis</subject><subject>MHC-I</subject><subject>Mice</subject><subject>Neuroblastoma</subject><subject>Neurology</subject><subject>Rats</subject><subject>RNA, Antisense</subject><subject>RNA, Messenger - metabolism</subject><subject>Teratocarcinoma</subject><subject>Transfection</subject><subject>Tumor Cells, Cultured - chemistry</subject><subject>Tumor Cells, Cultured - physiology</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rVDEUhoNY6lj9BwpZiOji1nx_bIQ62HagVZHuQyY5t0buxzS5V-q_N7czzNJVCOc5L-95EHpDyTklVH0inIiGW0E-WPWRMq1JQ5-hFTWaNdpq9hytjsgL9LKU34QQSaU4RafGMK4lWSH_I0OBIQAeW3x7vW422A8Rf2k07scOwtxBwWnA2U9Pg19z7wd836Wx9zhA1xUMj7uaUdJwX4kp1bQCeHN1WaP6n98uXqGT1ncFXh_eM3R3-fVufd3cfL_arC9umiAMn5qtBbrUtcZy743ebkX9RqGola0ApURLuDSaQ4wyMm3rxTYqMEwwIxU_Q-_3sbs8PsxQJtenshT0A4xzcVQawRTTFRR7MOSxlAyt2-XU-_zXUeIWsW6p4RZrzir3JNbRuvb2kD9ve4jHpYPJOn93mPsSfNdmP4RUjhinUiq9xHzeY1BV_EmQXQlp8R9ThjC5OKb_9_gHYVGQdQ</recordid><startdate>19960705</startdate><enddate>19960705</enddate><creator>Trojan, Jerzy</creator><creator>Duc, Huynh T.</creator><creator>Upegui-Gonzalez, L.C.</creator><creator>Hor, Frédéric</creator><creator>Guo, Yajun</creator><creator>Anthony, Donald</creator><creator>Ilan, Joseph</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19960705</creationdate><title>Presence of MHC-I and B-7 molecules in rat and human glioma cells expressing antisense IGF-I mRNA</title><author>Trojan, Jerzy ; Duc, Huynh T. ; Upegui-Gonzalez, L.C. ; Hor, Frédéric ; Guo, Yajun ; Anthony, Donald ; Ilan, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-b9e103049893aa87bb4030d46195f4e664f035873edd5d2791279d6e82428563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Antigens, CD - analysis</topic><topic>Antisense insulin-like growth factor I</topic><topic>B-7</topic><topic>B7-1 Antigen - analysis</topic><topic>B7-2 Antigen</topic><topic>Biological and medical sciences</topic><topic>Flow Cytometry</topic><topic>Gene Expression - physiology</topic><topic>Glioma</topic><topic>Histocompatibility Antigens Class I - analysis</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I - genetics</topic><topic>Insulin-Like Growth Factor II - genetics</topic><topic>Mammalia</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - analysis</topic><topic>MHC-I</topic><topic>Mice</topic><topic>Neuroblastoma</topic><topic>Neurology</topic><topic>Rats</topic><topic>RNA, Antisense</topic><topic>RNA, Messenger - metabolism</topic><topic>Teratocarcinoma</topic><topic>Transfection</topic><topic>Tumor Cells, Cultured - chemistry</topic><topic>Tumor Cells, Cultured - physiology</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trojan, Jerzy</creatorcontrib><creatorcontrib>Duc, Huynh T.</creatorcontrib><creatorcontrib>Upegui-Gonzalez, L.C.</creatorcontrib><creatorcontrib>Hor, Frédéric</creatorcontrib><creatorcontrib>Guo, Yajun</creatorcontrib><creatorcontrib>Anthony, Donald</creatorcontrib><creatorcontrib>Ilan, Joseph</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trojan, Jerzy</au><au>Duc, Huynh T.</au><au>Upegui-Gonzalez, L.C.</au><au>Hor, Frédéric</au><au>Guo, Yajun</au><au>Anthony, Donald</au><au>Ilan, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presence of MHC-I and B-7 molecules in rat and human glioma cells expressing antisense IGF-I mRNA</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1996-07-05</date><risdate>1996</risdate><volume>212</volume><issue>1</issue><spage>9</spage><epage>12</epage><pages>9-12</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Tumor cells frequently express the insulin-like growth factor I (IGF-I). Recently we demonstrated that rat glioma cells when transfected with a vector encoding antisense IGF-I cDNA lost tumorigenicity and induced a tumor specific immune response involving CD8+ lymphocytes. Here we show that the cultured transfected cell lines, rat C-6 glioma, human primary glioma and mouse teratocarcinoma, expressed an increased level of MHC-I and of co-signaling B-7 molecules. This increased expression of MHC-I and B-7, demonstrated by
51Cr release complement dependent cytoxicity assay and by immunostaining flow cytometry analysis, could contribute to the final immune recognition of glioma immunogenicity.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8823750</pmid><doi>10.1016/0304-3940(96)12770-1</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1996-07, Vol.212 (1), p.9-12 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antigens, CD - analysis Antisense insulin-like growth factor I B-7 B7-1 Antigen - analysis B7-2 Antigen Biological and medical sciences Flow Cytometry Gene Expression - physiology Glioma Histocompatibility Antigens Class I - analysis Humans Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor II - genetics Mammalia Medical sciences Membrane Glycoproteins - analysis MHC-I Mice Neuroblastoma Neurology Rats RNA, Antisense RNA, Messenger - metabolism Teratocarcinoma Transfection Tumor Cells, Cultured - chemistry Tumor Cells, Cultured - physiology Tumors of the nervous system. Phacomatoses |
| title | Presence of MHC-I and B-7 molecules in rat and human glioma cells expressing antisense IGF-I mRNA |
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