The activity of the gluconate-H super(+) symporter of Schizosaccharomyces pombe cells is down-regulated by D-glucose and exogenous cAMP
Schizosaccharomyces pombe cells take up D-gluconate, as an alternative carbon source for growth, during glucose starvation or when cultured on glycerol-containing medium. Gluconate uptake is not detectable while cells are growing logarithmically on glucose. The addition of D-glucose as well as its n...
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Veröffentlicht in: | FEBS letters 1996-10, Vol.395 (2-3), p.272-276 |
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description | Schizosaccharomyces pombe cells take up D-gluconate, as an alternative carbon source for growth, during glucose starvation or when cultured on glycerol-containing medium. Gluconate uptake is not detectable while cells are growing logarithmically on glucose. The addition of D-glucose as well as its non-metabolizable analogues to glycerol-grown cells causes an immediate loss of gluconate transport within 1 min. The reversible down-regulation of the gluconate carrier occurs after glucose has been internalized. This regulation is triggered not only by D-glucose but also by extracellular cAMP even in the absence of the cAMP-dependent protein kinase (PKA1). |
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source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Wiley Online Library All Journals; Alma/SFX Local Collection |
subjects | Schizosaccharomyces pombe |
title | The activity of the gluconate-H super(+) symporter of Schizosaccharomyces pombe cells is down-regulated by D-glucose and exogenous cAMP |
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