Enhancing effects of various gastric carcinogens on development of pepsinogen-altered pyloric glands in rats

To assess the possibility of establishing an in vivo, medium-term bioassay system for gastric carcinogens and promoters, a total of 220 male WKY rats were divided into two groups. Group 1 animals were treated first with a single dose of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) (160 mg/kg body wt)...

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Veröffentlicht in:	Carcinogenesis (New York) 1990-11, Vol.11 (11), p.1975-1978
Hauptverfasser:	Tatematsu, Masae, Ozaki, Keisuke, Mutai, Mamoru, Shichino, Yutaka, Furihata, Chie, Ito, Nobuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogenicity Tests Chemical agents Dimethyl Sulfoxide Gastric Mucosa - chemistry Gastric Mucosa - drug effects Male Medical sciences Methylnitronitrosoguanidine Pepsinogens - analysis Precancerous Conditions - chemically induced Precancerous Conditions - chemistry Pylorus - chemistry Rats Rats, Inbred WKY Stomach Neoplasms - chemically induced Stomach Neoplasms - chemistry Time Factors Tumors
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