Effect of gangliosides on binding, internalization and cytotoxic activity of ricin
The only gangliosides in Burkitts' lymphoma EB-3 cells is GM3. Treatment of Burkitts' lymphoma EB-3 cells with ganglosides GM1 or GM3 results in their binding to and partial incorporation into the cell membrane. About 25% of cell-associated ganglioside GM 1 can interact with the ricin. How...
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| Veröffentlicht in: | FEBS letters 1990-05, Vol.264 (2), p.249-252 |
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| creator | Tonevitsky, Alexander G. Zhukova, Olgad S. Mirimanova, Natalia V. Omelyanenko, Vladimir G. Timofeeva, Natalia V. Bergelson, Lev D. |
| description | The only gangliosides in Burkitts' lymphoma EB-3 cells is GM3. Treatment of Burkitts' lymphoma EB-3 cells with ganglosides GM1 or GM3 results in their binding to and partial incorporation into the cell membrane. About 25% of cell-associated ganglioside GM 1 can interact with the ricin. However, such an increase in the number of binding sites does not enhance but rather decreases the cytotoxic effect of ricin. A similar protective effect was observed when the cells were pretreated with ganglioside GM3. In contrast, the increase in ricin binding sites caused by pretreatment of the cells with neuraminidase was accompanied by increase in ricin cytotoxicity. These differences may be related to observed differences in the rate of ricin-endocytosis by native and ganglioside-treated cells. |
| doi_str_mv | 10.1016/0014-5793(90)80260-P |
| format | Article |
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Treatment of Burkitts' lymphoma EB-3 cells with ganglosides GM1 or GM3 results in their binding to and partial incorporation into the cell membrane. About 25% of cell-associated ganglioside GM 1 can interact with the ricin. However, such an increase in the number of binding sites does not enhance but rather decreases the cytotoxic effect of ricin. A similar protective effect was observed when the cells were pretreated with ganglioside GM3. In contrast, the increase in ricin binding sites caused by pretreatment of the cells with neuraminidase was accompanied by increase in ricin cytotoxicity. These differences may be related to observed differences in the rate of ricin-endocytosis by native and ganglioside-treated cells.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(90)80260-P</identifier><identifier>PMID: 2358071</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>ASM, anthrylvinyl-labeled sphingomyelin (N-12-(9-anthryl)-trans- dodecenoylsphingosine- 1-phosphocholine). Abbreviations of gangliosides follow the nomenclature of : GM1, Gal(β-3)GalNAc(βl-4)NeuAc(α-2-3)Gal(βl-4)Gal(βl-l)Cer ; Binding Sites ; Biological and medical sciences ; BSA, bovine serum albumin ; Burkitt Lymphoma ; Cell Membrane - metabolism ; Cell receptors ; Cell structures and functions ; Cell Survival - drug effects ; DMPC, 1,2-dimiristoyl-phosphatidylcholine ; Endocytosis ; Fundamental and applied biological sciences. Psychology ; G(M1) Ganglioside - metabolism ; G(M1) Ganglioside - pharmacology ; G(M2) Ganglioside - metabolism ; G(M2) Ganglioside - pharmacology ; Ganglioside ; ganglioside GM1 ; ganglioside GM3 ; Gangliosides - pharmacology ; GM3, NeuAc(α2-3Gal(βl-4)Glc(βl-1)Cer ; Liposomes - metabolism ; Miscellaneous ; Molecular and cellular biology ; Neuraminidase - metabolism ; Receptor ; Ricin ; Ricin - metabolism ; Ricin - toxicity ; Temperature ; Tumor Cells, Cultured</subject><ispartof>FEBS letters, 1990-05, Vol.264 (2), p.249-252</ispartof><rights>1990</rights><rights>FEBS Letters 264 (1990) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527P-816911ae5b69845b6fd1121eb4e166e906e9cab89095b27f6d5210b118e0b3e3</citedby><cites>FETCH-LOGICAL-c527P-816911ae5b69845b6fd1121eb4e166e906e9cab89095b27f6d5210b118e0b3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/001457939080260P$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19763320$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2358071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tonevitsky, Alexander G.</creatorcontrib><creatorcontrib>Zhukova, Olgad S.</creatorcontrib><creatorcontrib>Mirimanova, Natalia V.</creatorcontrib><creatorcontrib>Omelyanenko, Vladimir G.</creatorcontrib><creatorcontrib>Timofeeva, Natalia V.</creatorcontrib><creatorcontrib>Bergelson, Lev D.</creatorcontrib><title>Effect of gangliosides on binding, internalization and cytotoxic activity of ricin</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The only gangliosides in Burkitts' lymphoma EB-3 cells is GM3. Treatment of Burkitts' lymphoma EB-3 cells with ganglosides GM1 or GM3 results in their binding to and partial incorporation into the cell membrane. About 25% of cell-associated ganglioside GM 1 can interact with the ricin. However, such an increase in the number of binding sites does not enhance but rather decreases the cytotoxic effect of ricin. A similar protective effect was observed when the cells were pretreated with ganglioside GM3. In contrast, the increase in ricin binding sites caused by pretreatment of the cells with neuraminidase was accompanied by increase in ricin cytotoxicity. These differences may be related to observed differences in the rate of ricin-endocytosis by native and ganglioside-treated cells.</description><subject>ASM, anthrylvinyl-labeled sphingomyelin (N-12-(9-anthryl)-trans- dodecenoylsphingosine- 1-phosphocholine). Abbreviations of gangliosides follow the nomenclature of : GM1, Gal(β-3)GalNAc(βl-4)NeuAc(α-2-3)Gal(βl-4)Gal(βl-l)Cer</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>BSA, bovine serum albumin</subject><subject>Burkitt Lymphoma</subject><subject>Cell Membrane - metabolism</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cell Survival - drug effects</subject><subject>DMPC, 1,2-dimiristoyl-phosphatidylcholine</subject><subject>Endocytosis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>G(M1) Ganglioside - metabolism</subject><subject>G(M1) Ganglioside - pharmacology</subject><subject>G(M2) Ganglioside - metabolism</subject><subject>G(M2) Ganglioside - pharmacology</subject><subject>Ganglioside</subject><subject>ganglioside GM1</subject><subject>ganglioside GM3</subject><subject>Gangliosides - pharmacology</subject><subject>GM3, NeuAc(α2-3Gal(βl-4)Glc(βl-1)Cer</subject><subject>Liposomes - metabolism</subject><subject>Miscellaneous</subject><subject>Molecular and cellular biology</subject><subject>Neuraminidase - metabolism</subject><subject>Receptor</subject><subject>Ricin</subject><subject>Ricin - metabolism</subject><subject>Ricin - toxicity</subject><subject>Temperature</subject><subject>Tumor Cells, Cultured</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVFrFDEUhYNY6lr9Bwrzoih0NHcyk0leClp2q1Bwkb6HTObOcmU2qclsdfvrzXSX-iY-JCH3nHuSfGHsFfAPwEF-5Bzqsmm1eKf5e8Urycv1E7YA1YpS1FI9ZYtHyzP2PKUfPO8V6FN2WolG8RYW7PtyGNBNRRiKjfWbkUKiHlMRfNGR78lvzgvyE0ZvR7q3E2XB-r5w-ylM4Te5wrqJ7mjazxGRHPkX7GSwY8KXx_WM3ayWN5dfyutvV18vP12XrqnadalAagCLTSe1qvM89AAVYFcjSIma5-FspzTXTVe1g-ybCngHoJB3AsUZe3uIvY3h5w7TZLaUHI6j9Rh2yUCjRM3bOhvrg9HFkFLEwdxG2tq4N8DNTNLMmMyMyWhuHkiadW57fczfdVvsH5uO6LL-5qjb5Ow4ROsdpb_ZupVCVDz7VgffLxpx_19nm9XyczULc13zh-p8oYtDEGaod4TRJEfoHfYU8xeaPtC_X_QHeD2inQ</recordid><startdate>19900521</startdate><enddate>19900521</enddate><creator>Tonevitsky, Alexander G.</creator><creator>Zhukova, Olgad S.</creator><creator>Mirimanova, Natalia V.</creator><creator>Omelyanenko, Vladimir G.</creator><creator>Timofeeva, Natalia V.</creator><creator>Bergelson, Lev D.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>19900521</creationdate><title>Effect of gangliosides on binding, internalization and cytotoxic activity of ricin</title><author>Tonevitsky, Alexander G. ; Zhukova, Olgad S. ; Mirimanova, Natalia V. ; Omelyanenko, Vladimir G. ; Timofeeva, Natalia V. ; Bergelson, Lev D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527P-816911ae5b69845b6fd1121eb4e166e906e9cab89095b27f6d5210b118e0b3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>ASM, anthrylvinyl-labeled sphingomyelin (N-12-(9-anthryl)-trans- dodecenoylsphingosine- 1-phosphocholine). Abbreviations of gangliosides follow the nomenclature of : GM1, Gal(β-3)GalNAc(βl-4)NeuAc(α-2-3)Gal(βl-4)Gal(βl-l)Cer</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>BSA, bovine serum albumin</topic><topic>Burkitt Lymphoma</topic><topic>Cell Membrane - metabolism</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cell Survival - drug effects</topic><topic>DMPC, 1,2-dimiristoyl-phosphatidylcholine</topic><topic>Endocytosis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>G(M1) Ganglioside - metabolism</topic><topic>G(M1) Ganglioside - pharmacology</topic><topic>G(M2) Ganglioside - metabolism</topic><topic>G(M2) Ganglioside - pharmacology</topic><topic>Ganglioside</topic><topic>ganglioside GM1</topic><topic>ganglioside GM3</topic><topic>Gangliosides - pharmacology</topic><topic>GM3, NeuAc(α2-3Gal(βl-4)Glc(βl-1)Cer</topic><topic>Liposomes - metabolism</topic><topic>Miscellaneous</topic><topic>Molecular and cellular biology</topic><topic>Neuraminidase - metabolism</topic><topic>Receptor</topic><topic>Ricin</topic><topic>Ricin - metabolism</topic><topic>Ricin - toxicity</topic><topic>Temperature</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tonevitsky, Alexander G.</creatorcontrib><creatorcontrib>Zhukova, Olgad S.</creatorcontrib><creatorcontrib>Mirimanova, Natalia V.</creatorcontrib><creatorcontrib>Omelyanenko, Vladimir G.</creatorcontrib><creatorcontrib>Timofeeva, Natalia V.</creatorcontrib><creatorcontrib>Bergelson, Lev D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tonevitsky, Alexander G.</au><au>Zhukova, Olgad S.</au><au>Mirimanova, Natalia V.</au><au>Omelyanenko, Vladimir G.</au><au>Timofeeva, Natalia V.</au><au>Bergelson, Lev D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of gangliosides on binding, internalization and cytotoxic activity of ricin</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1990-05-21</date><risdate>1990</risdate><volume>264</volume><issue>2</issue><spage>249</spage><epage>252</epage><pages>249-252</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>The only gangliosides in Burkitts' lymphoma EB-3 cells is GM3. Treatment of Burkitts' lymphoma EB-3 cells with ganglosides GM1 or GM3 results in their binding to and partial incorporation into the cell membrane. About 25% of cell-associated ganglioside GM 1 can interact with the ricin. However, such an increase in the number of binding sites does not enhance but rather decreases the cytotoxic effect of ricin. A similar protective effect was observed when the cells were pretreated with ganglioside GM3. In contrast, the increase in ricin binding sites caused by pretreatment of the cells with neuraminidase was accompanied by increase in ricin cytotoxicity. These differences may be related to observed differences in the rate of ricin-endocytosis by native and ganglioside-treated cells.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2358071</pmid><doi>10.1016/0014-5793(90)80260-P</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1990-05, Vol.264 (2), p.249-252 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | ASM, anthrylvinyl-labeled sphingomyelin (N-12-(9-anthryl)-trans- dodecenoylsphingosine- 1-phosphocholine). Abbreviations of gangliosides follow the nomenclature of : GM1, Gal(β-3)GalNAc(βl-4)NeuAc(α-2-3)Gal(βl-4)Gal(βl-l)Cer Binding Sites Biological and medical sciences BSA, bovine serum albumin Burkitt Lymphoma Cell Membrane - metabolism Cell receptors Cell structures and functions Cell Survival - drug effects DMPC, 1,2-dimiristoyl-phosphatidylcholine Endocytosis Fundamental and applied biological sciences. Psychology G(M1) Ganglioside - metabolism G(M1) Ganglioside - pharmacology G(M2) Ganglioside - metabolism G(M2) Ganglioside - pharmacology Ganglioside ganglioside GM1 ganglioside GM3 Gangliosides - pharmacology GM3, NeuAc(α2-3Gal(βl-4)Glc(βl-1)Cer Liposomes - metabolism Miscellaneous Molecular and cellular biology Neuraminidase - metabolism Receptor Ricin Ricin - metabolism Ricin - toxicity Temperature Tumor Cells, Cultured |
| title | Effect of gangliosides on binding, internalization and cytotoxic activity of ricin |
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